Shigella flexneri 4c strain 1205

Gram-negativeRodMotileFacultative

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Shigella

Description

Shigella flexneri 4c strain 1205 is a pathogenic, Gram-negative bacterium known for its role in causing severe gastrointestinal diseases in humans and other primates. This organism is a rod-shaped, facultative anaerobe that typically thrives at an optimal temperature of 37°C, making it mesophilic. The bacterium exhibits mobility, facilitated by the presence of flagella, and it typically exists in pairs or singles within its habitat, which is primarily associated with hosts such as Homo sapiens and certain primates. S. flexneri 4c strain 1205 is classified as a chemoorganotroph, obtaining energy from organic compounds. It has a complex cellular structure comprising two membranes and four replicons, which are indicative of its genetic organization. This strain does not form spores and is free-living in its environment. The health impacts of this strain are significant, as it is associated with various forms of dysentery, including shigellosis and bacillary dysentery. These infections can lead to severe diarrhea, posing a considerable public health challenge, especially in areas with inadequate sanitation. Ecologically, the presence of S. flexneri 4c strain 1205 highlights the intricate relationships between pathogenic bacteria and their hosts. As a free-living organism that can cause disease, it underscores the importance of understanding microbial dynamics in human and primate populations, particularly in the context of disease transmission and outbreaks. The ability of this strain to adapt to its hosts and environmental conditions reflects the ongoing evolutionary interactions within microbial communities.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusShigella
SpeciesShigella flexneri
Strain4c strain 1205

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Shigella flexneri 4c strain 1205
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Primates, Pteropodidae
Cell arrangementPairs-Singles
SporulationNonsporulating
Energy source Chemoorganotroph
PathogenicityHuman

Genome Summary

Shigella flexneri 4c strain 1205 plasmid 1205p1, complete

Gene Summary

Adenine Count

66693 bp

Thymine Count

66478 bp

Guanine Count

58195 bp

Cytosine Count

57002 bp

Genome Length

248368 bp

Protein-coding Genes

261 genes

Non-Coding Genes

22 genes

# of Chromosomes/Plasmids

4

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
omptin family outer membrane protease icspAD871_RS29620Not AvailableNegative191 - 56113017.5
omptin family outer membrane protease icspAD871_RS29625Not AvailablePositive806 - 9254907.91
type 3 secretion system effector ospbAD871_RS26545Not AvailablePositive1176 - 204232422.7
pap2 family phosphatase phon2AD871_RS26550Not AvailablePositive2371 - 311127574.6
hypothetical proteinAD871_RS31045Not AvailablePositive3184 - 33064362.17
omptin family outer membrane protease icspAD871_RS30230Not AvailableNegative3464 - 491954082.4
omptin family outer membrane protease icspAD871_RS26565Not AvailableNegative5286 - 580419215.2
omptin family outer membrane protease icspAD871_RS26570Not AvailableNegative5821 - 60579159.94
omptin family outer membrane protease icspAD871_RS26575Not AvailableNegative6108 - 726442052.0
shet2/espl2 family type iii secretion system effector toxinAD871_RS26580Not AvailableNegative7436 - 914565076.6

Displaying genes 1 – 10 of 5400 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

73 records
Metabolite IDMetabolite nameStructureCAS number
BASm0001885Tetra-mu3-sulfido-tetrairon(1+)Fe4S4Chemical structure of Tetra-mu3-sulfido-tetrairon(1+)Not available
Average351.62Da
Monoisotopic351.62748Da
BASm00055001-octadecanoyl-sn-glycero-3-phosphateC21H41O7PChemical structure of 1-octadecanoyl-sn-glycero-3-phosphateNot available
Average436.5198Da
Monoisotopic436.2589902Da
BASm0014033AmmoniaH3NChemical structure of Ammonia7664-41-7
Average17.0305Da
Monoisotopic17.026549101Da
BASm0014041Oleic acidC18H34O2Chemical structure of Oleic acid112-80-1
Average282.4614Da
Monoisotopic282.255880332Da
BASm0014042Oxoglutaric acidC5H6O5Chemical structure of Oxoglutaric acid328-50-7
Average146.0981Da
Monoisotopic146.021523302Da
BASm0014058Myristic acidC14H28O2Chemical structure of Myristic acid544-63-8
Average228.3709Da
Monoisotopic228.20893014Da
BASm0014219Palmitoleic acidC16H30O2Chemical structure of Palmitoleic acidNULL
Average254.4082Da
Monoisotopic254.224580204Da
BASm0017263NADPC21H29N7O17P3Chemical structure of NADP53-59-8
Average744.4129Da
Monoisotopic744.083277073Da
BASm0017280Phosphohydroxypyruvic acidC3H5O7PChemical structure of Phosphohydroxypyruvic acid3913-50-6
Average184.0414Da
Monoisotopic183.977289026Da
BASm00173723-PhosphoglycerateC3H7O7PNot available820-11-1
Average186.056Da
Monoisotopic185.992939563Da

Displaying 1–10 of 73 metabolites

Health Effects

Health ConditionRelationReference
ShigellosisCausesPMC2600399
ShigellosisCausesPMC5109407
ShigellosisCausesPMC5177732
Severe diarrheaCausesPMC8742002
Dysenteric diseaseCausesPMC8742002
ShigellosisCausesPMC8742002
Bacillary dysenteryCausesPMC8742002
Pandemic dysenteryCausesPMC8742002
Bacillary dysenteryCausesPMC4159516
ShigellosisCausesPMC5429569

Displaying health effects 1 – 10 of 10 in total