Neisseria meningitidis strain N43_16

Neisseria meningitidis strain N43_16 is a Gram-negative cocci bacterium that occurs in pairs and is characterized by its aerobic lifestyle. This strain is mesophilic, with an optimal growth temperature of 35°C and a temperature range suitable for growth in moderate conditions. N43_16 does not exhibit mobility, as it lacks flagella, and has a complex structure with two membranes and a single replicon. The primary habitat of N43_16 is host-associated, specifically within Homo sapiens, where it can lead to various health complications. The strain is known to cause severe health issues, including meningitis, septicemia, cellulitis, and invasive meningococcal disease (IMD). These conditions can manifest as bacterial meningitis and acute bacterial meningitis, underscoring the pathogen's significant impact on human health. N43_16's biotic relationship is described as free-living, although it primarily resides within a host. This dual nature may contribute to its ability to transition between environmental and host-associated states, making it a pathogen of public health concern. The understanding of such traits is critical for developing effective strategies to combat the diseases associated with N. meningitidis. The strain's ability to cause severe infections emphasizes the importance of monitoring and researching its ecological and biological behaviors as a means to mitigate its health impacts.