Neisseria meningitidis strain N473_12

Neisseria meningitidis strain N473_12 is a Gram-negative bacterium characterized by its coccoid shape and arrangement in pairs. As an aerobic organism, it requires oxygen for survival and growth. This strain is non-motile, lacking flagella, and is classified as mesophilic, with an optimal growth temperature of 35°C, indicating it thrives in moderate temperature conditions. N473_12 is notable for its association with human hosts, specifically Homo sapiens, and is known for its pathogenic potential. It is implicated in several severe health conditions, including meningitis, sepsis, cellulitis, and invasive meningococcal disease (IMD). The organism can lead to acute bacterial meningitis (ABM) and meningococcal septicemia, reflecting its capacity to cause significant morbidity and mortality in affected individuals. With a single replicon and two membranes, N473_12's structure is typical of Gram-negative bacteria, which contributes to its resilience in various environments. While primarily host-associated, this strain is also noted for its free-living biotic relationship, suggesting some ecological flexibility. Understanding the traits of Neisseria meningitidis strain N473_12 is crucial for public health, given its role in invasive diseases. The bacterium's unique characteristics, particularly its oxygen dependence and pathogenic nature, underscore the importance of surveillance and preventive measures in managing meningococcal infections in human populations.