Shigella flexneri strain 551537

Gram-negativeRodMotileFacultative

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Shigella

Description

Shigella flexneri strain 551537 is a pathogenic bacterium primarily associated with human hosts, specifically Homo sapiens, but it is also found in some primates and certain species of bats (Pteropodidae). This gram-negative organism exhibits a rod shape and can be observed in pairs or singles. As a chemoorganotroph, it derives energy from organic compounds, and it has a facultative oxygen requirement, allowing it to thrive in varying oxygen conditions. The strain is motile, possessing flagella, which may contribute to its pathogenic capabilities. It is mesophilic, with an optimal growth temperature of 37°C, aligning with the human body temperature, which facilitates its survival and replication in a host environment. Shigella flexneri strain 551537 has a single replicon and features a double membrane structure, characteristic of gram-negative bacteria. This bacterium is notable for causing severe health effects, including shigellosis, characterized by dysentery and severe diarrhea. It is recognized for its role in pandemic dysentery outbreaks, highlighting its significant public health impact. The nonsporulating nature of this strain indicates that it does not form spores, which may affect its survival strategies outside a host. In summary, Shigella flexneri strain 551537 illustrates the complex ecological relationship between pathogenic bacteria and their hosts, emphasizing the importance of understanding such pathogens in the context of public health and disease prevention.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusShigella
SpeciesShigella flexneri
Strainstrain 551537

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Shigella flexneri strain 551537
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Primates, Pteropodidae
Cell arrangementPairs-Singles
SporulationNonsporulating
Energy source Chemoorganotroph
PathogenicityHuman

Genome Summary

Shigella flexneri strain 551537

Gene Summary

Adenine Count

1080244 bp

Thymine Count

1066209 bp

Guanine Count

1105534 bp

Cytosine Count

1107712 bp

Genome Length

4381487 bp

Protein-coding Genes

4148 genes

Non-Coding Genes

247 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
histidinol dehydrogenaseDOU91_02200Not AvailablePositive433113 - 43441746184.0
histidinol-phosphate transaminaseDOU91_02205Not AvailablePositive434414 - 43548439328.4
bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydrataseDOU91_02210Not AvailablePositive435484 - 43655140234.3
imidazole glycerol phosphate synthase subunit hishDOU91_02215Not AvailablePositive436551 - 43714121654.1
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomeraseDOU91_02220Not AvailablePositive437141 - 43787826046.2
imidazole glycerol phosphate synthase cyclase subunitDOU91_02225Not AvailablePositive437860 - 43863628442.0
bifunctional phosphoribosyl-amp cyclohydrolase/phosphoribosyl-atp diphosphatase hisieDOU91_02230Not AvailablePositive438630 - 43924122827.2
hypothetical proteinDOU91_02235Not AvailablePositive439238 - 4394296844.21
lps o-antigen chain length determinant protein wzzbDOU91_02240Not AvailableNegative439338 - 44031536129.5
nad-dependent epimeraseDOU91_02250Not AvailablePositive440724 - 44172837653.9

Displaying genes 651 – 660 of 4396 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

11 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001779orotateC5H3N2O4Chemical structure of orotateNot available
Average155.09Da
Monoisotopic155.0098302Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002051D-fructoseC6H12O6Chemical structure of D-fructose57-48-7
Average180.1559Da
Monoisotopic180.0633881Da
BASm0002780orotidine 5'-phosphateC10H10N2O11PNot available2149-82-8
Average365.168Da
Monoisotopic365.003866888Da
BASm0003333(2R)-3-phosphoglycerateC3H4O7PChemical structure of (2R)-3-phosphoglycerateNot available
Average183.033Da
Monoisotopic182.9711102Da
BASm0003346(2R)-2-phosphoglycerateC3H4O7PChemical structure of (2R)-2-phosphoglycerateNot available
Average183.033Da
Monoisotopic182.9711102Da
BASm0003389NADP(+)C21H25N7O17P3Chemical structure of NADP(+)Not available
Average740.386Da
Monoisotopic740.053624107Da
BASm0003491(2S)-2-acetolactateC5H7O4Chemical structure of (2S)-2-acetolactateNot available
Average131.108Da
Monoisotopic131.0349823Da

Displaying 1–10 of 11 metabolites

Health Effects

Health ConditionRelationReference
ShigellosisCausesPMC2600399
ShigellosisCausesPMC5109407
ShigellosisCausesPMC5177732
Severe diarrheaCausesPMC8742002
Dysenteric diseaseCausesPMC8742002
ShigellosisCausesPMC8742002
Bacillary dysenteryCausesPMC8742002
Pandemic dysenteryCausesPMC8742002
Bacillary dysenteryCausesPMC4159516
ShigellosisCausesPMC5429569

Displaying health effects 1 – 10 of 10 in total