Cronobacter sakazakii strain ATCC 29544

Gram-negativeRodNon-motileAnaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Cronobacter

Description

Cronobacter sakazakii strain ATCC 29544 is a Gram-negative, rod-shaped bacterium that is classified as an anaerobe, indicating its capacity to thrive in environments devoid of oxygen. This strain is characterized by its non-motility and presence of flagella. It has been identified as a free-living organism, typically found in a host-associated habitat, and is mesophilic with an optimal growth temperature of 37°C. The strain has a complex genomic structure with four replicons, and it has been documented to inhabit various hosts, including Homo sapiens, Viridiplantae, Amphibia, Gastrotheca, and Cucumis sativus. Notably, this strain is recognized for its pathogenic potential in humans, linked to serious health issues such as meningitis, sepsis, septicemia, and necrotizing enterocolitis (NEC). It can also cause mild diseases and has been associated with brain abscesses or lesions. The ecological role of Cronobacter sakazakii strain ATCC 29544 is significant, as its ability to inhabit a variety of hosts suggests a versatile adaptability to different environmental conditions. This adaptability could play a critical role in its transmission dynamics and pathogenicity, particularly in vulnerable populations such as infants and immunocompromised individuals. Understanding the biology and ecology of this strain helps elucidate its impact on health and disease.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusCronobacter
SpeciesCronobacter sakazakii
Strainstrain ATCC 29544

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranesNot Available
Image of Cronobacter sakazakii strain ATCC 29544
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Viridiplantae, Amphibia
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Cronobacter sakazakii strain ATCC 29544


Gene Summary

Adenine Count

19722 bp

Thymine Count

20642 bp

Guanine Count

26775 bp

Cytosine Count

26766 bp

Genome Length

93905 bp

Protein-coding Genes

67 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

4

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Phage antirepressor proteinCSK29544_RS25125Not AvailableNegative58 - 45814576.2
lysis system i-spanin subunit rzCSK29544_RS22125Not AvailableNegative1064 - 11684195.94
Homing endonucleaseCSK29544_RS22130Not AvailableNegative1172 - 166918860.6
lysis proteinCSK29544_RS24785Not AvailableNegative1638 - 17996172.14
EndopeptidaseCSK29544_RS00015Q9XJJ6Negative1727 - 213114812.0
Phage lysozymeCSK29544_RS00020Not AvailableNegative2121 - 261517956.8
Hypothetical proteinCSK29544_RS00025Not AvailableNegative2624 - 290510577.5
AttlNot AvailableNot AvailablePositive3416 - 3428Not Available
Late gene regulator qCSK29544_RS00030Not AvailableNegative3693 - 445727872.6
hypothetical proteinCSK29544_RS00035Not AvailableNegative4454 - 46336863.19

Displaying genes 1 – 10 of 4541 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

5 records
Metabolite IDMetabolite nameStructureCAS number
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002981N(6)-hydroxy-L-lysineC6H14N2O3Chemical structure of N(6)-hydroxy-L-lysineNot available
Average162.189Da
Monoisotopic162.1004423Da
BASm0003212N(6)-acetyl-N(6)-hydroxy-L-lysineC8H16N2O4Chemical structure of N(6)-acetyl-N(6)-hydroxy-L-lysineNot available
Average204.226Da
Monoisotopic204.111007003Da
BASm0003389NADP(+)C21H25N7O17P3Chemical structure of NADP(+)Not available
Average740.386Da
Monoisotopic740.053624107Da
BASm0004512N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysineC14H19N2O10Chemical structure of N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysineNot available
Average375.312Da
Monoisotopic375.1056156Da

Displaying 1–5 of 5 metabolites

Health Effects

Health ConditionRelationReference
Mild diseasesCausesPMC5615607
Bacterial meningitisCausesPMC10370310
SepsisCausesPMC10370310
Necrotizing enterocolitisCausesPMC11267904
NecCausesPMC11267904
SepsisCausesPMC11267904
MeningitisCausesPMC11267904
Necrotizing enterocolitisCausesPMC1868726
BacteraemiaCausesPMC1868726
MeningitisCausesPMC1868726

Displaying health effects 1 – 10 of 19 in total