Prevotella melaninogenica ATCC 25845

Gram-negativeRodNon-motileAnaerobe

Kingdom

Pseudomonadati

Phylum

Bacteroidota

Class

Bacteroidia

Order

Bacteroidales

Family

Prevotellaceae

Genus

Prevotella

Description

Prevotella melaninogenica ATCC 25845 is a mesophilic, Gram-negative, rod-shaped bacterium that belongs to the family Prevotellaceae. As a chemoheterotroph, it derives its energy from the breakdown of organic compounds, utilizing a variety of carbon sources as its energy source. This bacterium is capable of producing energy through the process of fermentation, where it converts glucose and other sugars into lactate, ethanol, and carbon dioxide. P. melaninogenica ATCC 25845 is classified as a facultative anaerobe, meaning it can grow in both aerobic and anaerobic environments. It exhibits a growth preference for microaerobic conditions, where oxygen levels are moderate, making it thrive in areas with limited oxygen availability. Its cell shape is characterized by a rod-like morphology, with dimensions ranging from 0.5-1.5 μm in width and 2-5 μm in length. P. melaninogenica ATCC 25845 is commonly found in the oral cavity, respiratory tract, and gastrointestinal tract of humans, as well as in soil and sediments. The bacterium's metabolic capabilities are supplemented by its ability to produce melanin, a pigment produced through the oxidation of tyrosine. This unique characteristic allows it to thrive in environments with high levels of tyrosine, such as those found in soil and decaying matter. In addition to its vital functions in the ecosystem, P. melaninogenica ATCC 25845 has earned recognition for its potential role in human health. Research has indicated that this microbe is involved in the breakdown of complex lipids and the production of bioactive compounds, which may have therapeutic applications. Furthermore, studies have suggested that alterations in the gut microbiome, including changes in the presence of P. melaninogenica ATCC 25845, may be associated with various human diseases, such as inflammatory bowel disease and colon cancer.

Taxonomy

KingdomPseudomonadati
PhylumBacteroidota
ClassBacteroidia
OrderBacteroidales
FamilyPrevotellaceae
GenusPrevotella
SpeciesPrevotella melaninogenica
StrainATCC 25845

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Prevotella melaninogenica ATCC 25845
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementNot Available
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Prevotella melaninogenica ATCC 25845


Gene Summary

Adenine Count

406073 bp

Thymine Count

402426 bp

Guanine Count

281778 bp

Cytosine Count

281597 bp

Genome Length

1371874 bp

Protein-coding Genes

1001 genes

Non-Coding Genes

16 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
peptidaseHMPREF0659_RS12200Not AvailableNegative1361075 - 136134410823.3
sodium-translocating pyrophosphataseHMPREF0659_RS12205Not AvailableNegative1362480 - 136468776559.2
nitroreductase family proteinHMPREF0659_RS12210Not AvailableNegative1365369 - 136610027798.3
adenosylcobalamin-dependent ribonucleoside-diphosphate reductaseHMPREF0659_RS12215Not AvailablePositive1366198 - 136879898495.0
dihydroneopterin aldolaseHMPREF0659_RS12220Not AvailablePositive1368937 - 136932013982.1
n-acetylmuramoyl-l-alanine amidaseHMPREF0659_RS12225Not AvailablePositive1369373 - 137070449368.4
mlad family proteinHMPREF0659_RS12230Not AvailablePositive1370716 - 137169635338.9
right-handed parallel beta-helix repeat-containing proteinHMPREF0659_RS00005Not AvailablePositive504 - 3407105853.0
duf6377 domain-containing proteinHMPREF0659_RS00010Not AvailablePositive3581 - 517662736.6
ribonuclease iiiHMPREF0659_RS00015Not AvailableNegative5784 - 684840281.8

Displaying genes 1011 – 1020 of 2452 in total

Metabolites

272 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001035indole-3-pyruvateC11H8NO3Chemical structure of indole-3-pyruvate35656-49-6
Average202.1861Da
Monoisotopic202.0504181Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001639CobinamideC48H72CoN11O8Chemical structure of Cobinamide13497-85-3
Average990.0874Da
Monoisotopic989.4897335Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm0001921(S)-3-methyl-2-oxopentanoateC6H9O3Chemical structure of (S)-3-methyl-2-oxopentanoate1460-34-0
Average129.1339Da
Monoisotopic129.0551692Da
BASm00022412-demethylmenaquinone-8C50H70O2Chemical structure of 2-demethylmenaquinone-8Not available
Average703.0896Da
Monoisotopic702.5375815Da

Displaying 1–10 of 272 metabolites

Health Effects

Health ConditionRelationReference
PeriodontitisCausesPMC1681585
PneumoniaCausesPMC1681585

Displaying health effects 1 – 2 of 2 in total