Bifidobacterium animalis subsp. lactis BB-12

Gram-positiveRodNon-motileAnaerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Bifidobacteriales

Family

Bifidobacteriaceae

Genus

Bifidobacterium

Description

Bifidobacterium animalis subsp. lactis BB-12 is a gram-positive, rod-shaped bacterium that thrives in mesophilic conditions, classified as a facultative anaerobe and a heterotroph, capable of metabolizing a variety of carbohydrates. This probiotic microorganism is predominantly found in the human gastrointestinal tract, particularly in the colon, as well as in the intestines of various animals, including livestock and pets. Its ability to adapt to environments rich in nutrients makes it a prominent member of the gut microbiota. The gram-positive nature of BB-12 indicates a thick peptidoglycan layer in its cell wall, a characteristic that contributes to its stability and resilience in acidic environments, such as the stomach. Its rod shape is typical of many bifidobacteria, allowing for efficient colonization and interaction with the gut lining. BB-12's preferring mesophilic conditions indicates it thrives optimally between 30-37°C, which aligns well with the human body temperature, facilitating its presence as a beneficial gut inhabitant. As a facultative anaerobe, BB-12 can grow in both the presence or absence of oxygen, which enables it to thrive in various niches within the gut. Its heterotrophic metabolism means it relies on organic compounds for energy, primarily fermenting carbohydrates to produce beneficial short-chain fatty acids, aiding in gut health and regulation of intestinal microbiota. Bifidobacterium animalis subsp. lactis BB-12 is particularly revered in the food and health industries for its probiotic properties, enhancing gut health, improving lactose digestion, and modulating the immune response. Research has shown that this strain can potentially reduce the risk of gastrointestinal disorders and contribute to overall well-being when included in functional foods and dietary supplements. Its ability to survive in processed dairy products further underscores its significance in functional nutrition and public health.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderBifidobacteriales
FamilyBifidobacteriaceae
GenusBifidobacterium
SpeciesBifidobacterium animalis
Strainsubsp. lactis BB-12

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Bifidobacterium animalis subsp. lactis BB-12
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature39
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementNot Available
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Bifidobacterium animalis subsp. lactis BB-12


Gene Summary

Adenine Count

383455 bp

Thymine Count

384690 bp

Guanine Count

587452 bp

Cytosine Count

588555 bp

Genome Length

1944152 bp

Protein-coding Genes

1556 genes

Non-Coding Genes

67 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
chromosomal replication initiator protein dnaaBIF_RS00005Not AvailablePositive1 - 175264805.0
dna polymerase iii subunit betaBIF_RS00010Not AvailablePositive2356 - 348040668.3
dna replication/repair protein recfBIF_RS00015Not AvailablePositive3526 - 495351830.4
dcia family proteinBIF_RS00020Not AvailablePositive4950 - 545318849.8
dna topoisomerase (atp-hydrolyzing) subunit bBIF_RS00025Not AvailablePositive5644 - 776178154.8
dna gyrase subunit aBIF_RS00030Not AvailablePositive7830 - 10592102097.0
duf3566 domain-containing proteinBIF_RS00035Not AvailablePositive10718 - 1125419102.4
vanz family proteinBIF_RS00040Not AvailablePositive11458 - 1253140800.6
paqr family membrane homeostasis protein trhaBIF_RS00045Not AvailableNegative12612 - 1340629726.5
nadp-specific glutamate dehydrogenaseBIF_RS00050Not AvailableNegative13885 - 1523149032.9

Displaying genes 1 – 10 of 1623 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

283 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001035indole-3-pyruvateC11H8NO3Chemical structure of indole-3-pyruvate35656-49-6
Average202.1861Da
Monoisotopic202.0504181Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001360methanesulfonateCH3O3SChemical structure of methanesulfonate59721-29-8
Average95.09Da
Monoisotopic94.980838711Da
BASm0001639CobinamideC48H72CoN11O8Chemical structure of Cobinamide13497-85-3
Average990.0874Da
Monoisotopic989.4897335Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm0001921(S)-3-methyl-2-oxopentanoateC6H9O3Chemical structure of (S)-3-methyl-2-oxopentanoate1460-34-0
Average129.1339Da
Monoisotopic129.0551692Da

Displaying 1–10 of 283 metabolites

Health Effects

No health effects information available for this bacterium.