Cronobacter sakazakii ATCC BAA-894

Gram-negativeRodNon-motileAnaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Cronobacter

Description

Cronobacter sakazakii ATCC BAA-894 is a gram-negative, rod-shaped bacterium that thrives in mesophilic conditions, showing a temperature preference of around 30-37°C. As a chemoheterotroph, it relies on organic compounds for energy and carbon, making it adaptable to various environments. This bacterium is classified as a facultative anaerobe, allowing it to grow in the presence or absence of oxygen, although it prefers aerobic conditions. Cronobacter sakazakii is known for its presence in various environments, notably in dried foods such as powdered infant formula and other food products. Its versatility allows it to inhabit not only food sources but also environmental niches like soil and water. The ability to survive desiccation and resist harsh conditions makes it a significant concern for food safety. This pathogen can colonize the gastrointestinal tract, and its implications are particularly severe in neonates and immunocompromised individuals, leading to conditions like meningitis and enteritis. In terms of pathogenicity, Cronobacter sakazakii has been associated with severe infections, especially in infants, where it may cause necrotizing enterocolitis. It can produce biofilms, contributing to its persistence in food-processing environments, complicating efforts at decontamination. Furthermore, this microbe exhibits resistance to multiple antibiotics, raising concerns in clinical settings regarding treatment efficacy. In addition to its health implications, research has demonstrated that Cronobacter sakazakii possesses unique biochemical properties that allow for the production of various enzymes, leading to potential applications in biotechnology. The ongoing study of this bacterium continues to shed light on its role in food safety and human health, making it a subject of great scientific interest.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusCronobacter
SpeciesCronobacter sakazakii
StrainATCC BAA-895

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceNot Available
Number of membranesNot Available
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Cronobacter sakazakii ATCC BAA-894

Accession NumberNC_009780.1

Gene Summary

Adenine Count

Not Available

Thymine Count

Not Available

Guanine Count

Not Available

Cytosine Count

Not Available

Genome Length

Not Available

Protein-coding Genes

116 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
histidine phosphatase family proteinESA_RS20640Not Available+957 - 157422384.5
membrane proteinESA_RS20645Not Available+1673 - 244027366.5
parb/srx family n-terminal domain-containing proteinESA_RS20650Not Available+2564 - 362240571.0
gnat family n-acetyltransferaseESA_RS20655Not Available-3627 - 415720027.5
mfs transporterESA_RS20660Not Available+4454 - 566242288.3
omptin family outer membrane protease cpaESA_RS20665Not Available+5978 - 691635095.5
carbapenem self-resistance protein carg family proteinESA_RS20670Not Available+7165 - 770719820.1
hypothetical proteinESA_RS20675Not Available+7704 - 824320018.4
helix-turn-helix transcriptional regulatorESA_RS20680Not Available+8276 - 897126377.1
voc family proteinESA_RS20685Not Available+9028 - 941114570.5

Displaying genes 1 – 10 of 4325 in total

Pathways

1 pathway

Metabolites

13 records
Metabolite IDMetabolite nameStructureCAS number
BASm0002963meso-2,6-diaminoheptanedioateC7H14N2O4Chemical structure of meso-2,6-diaminoheptanedioate922-54-3
Average190.1971Da
Monoisotopic190.0953569Da
BASm0003983di-trans,octa-cis-undecaprenyl phosphateC55H89O4PChemical structure of di-trans,octa-cis-undecaprenyl phosphateNot available
Average845.288Da
Monoisotopic844.6509455Da
BASm0004094di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineC95H152N8O28P2Chemical structure of di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineNot available
Average1916.239Da
Monoisotopic1915.021324602Da
BASm0004925UDP-N-acetyl-alpha-D-muramateC20H28N3O19P2Chemical structure of UDP-N-acetyl-alpha-D-muramateNot available
Average676.395Da
Monoisotopic676.080870429Da
BASm0017263NADPC21H29N7O17P3Chemical structure of NADP53-59-8
Average744.4129Da
Monoisotopic744.083277073Da
BASm0017265Uridine diphosphate-N-acetylglucosamineC17H27N3O17P2Chemical structure of Uridine diphosphate-N-acetylglucosamine528-04-1
Average607.3537Da
Monoisotopic607.081569477Da
BASm0017326Undecaprenyl diphosphateC55H92O7P2Chemical structure of Undecaprenyl diphosphate23-13-2
Average927.2623Da
Monoisotopic926.631828322Da
BASm0017378UDP-N-Acetylmuramoyl-L-alanyl-D-glutamateC22H32Cl2N2O4Chemical structure of UDP-N-Acetylmuramoyl-L-alanyl-D-glutamate17088-64-1
Average459.41Da
Monoisotopic458.1739129Da
BASm0017566UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelateC35H55N7O26P2Chemical structure of UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelateNULL
Average1051.79Da
Monoisotopic1051.267197991Da
BASm0017571Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineC95H157N9O27P2Chemical structure of Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineNULL
Average1919.2547Da
Monoisotopic1918.066413887Da

Displaying 1–10 of 13 metabolites