Streptomyces avermitilis

Gram-positiveTailedMotileAerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Kitasatosporales

Family

Streptomycetaceae

Genus

Streptomyces

Description

Streptomyces avermitilis is a gram-positive, filamentous bacterium characterized by its rod shape, mesophilic temperature preference, heterotrophic metabolism, and obligate aerobic nature. As a member of the Streptomyces genus, it exhibits a complex life cycle and forms branched filaments resembling fungal hyphae, which further distinguishes it from other bacterial species. The gram-positive nature of S. avermitilis is indicative of its thick peptidoglycan cell wall, which is vital for its structural integrity and resilience in various environments. Being mesophilic, S. avermitilis thrives optimally at moderate temperatures, typically between 25°C and 37°C, making it well-suited for life in soil and decaying organic matter. As a heterotroph, it derives energy and carbon from organic compounds, efficiently breaking down complex substrates and playing a crucial role in the carbon cycle. Its obligate aerobic classification necessitates the presence of oxygen for respiration, which is essential for its metabolic processes and energy production. S. avermitilis is noteworthy for its ability to produce a variety of bioactive compounds, most famously avermectins, which are used as antiparasitic agents in veterinary medicine and agriculture. The discovery of these compounds has revolutionized parasite control in both livestock and crops, leading to significant economic benefits. Additionally, this bacterium has a rich history in the field of biotechnology, as it has been studied extensively for its potential in natural product discovery, contributing to our understanding of microbial ecology and the development of new therapeutic agents. Its ability to decompose complex organic materials also highlights its ecological importance in nutrient recycling and soil health.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderKitasatosporales
FamilyStreptomycetaceae
GenusStreptomyces
SpeciesStreptomyces avermitilis
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeTailed
MobilityYes
Flagellar presenceYes
Number of membranes1
Image of Streptomyces avermitilis
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe
Optimal temperature25
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Arabidopsis thaliana
Cell arrangementNot Available
SporulationSporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Streptomyces avermitilis NBRC 14893 DNA, contig6, whole genome

Gene Summary

Adenine Count

1543547 bp

Thymine Count

1545626 bp

Guanine Count

3710087 bp

Cytosine Count

3685248 bp

Genome Length

10484508 bp

Protein-coding Genes

9908 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
udp-glucose 4-epimeraseSAV14893_000010Not AvailablePositive1093 - 205833301.0
ndp-hexose 2,3-dehydrataseSAV14893_000020Not AvailableNegative2851 - 424551720.6
hypothetical proteinSAV14893_000030Not AvailableNegative4258 - 485722368.6
hypothetical proteinSAV14893_000040Not AvailableNegative4748 - 616051120.9
thioesteraseSAV14893_000050Not AvailablePositive6398 - 715027331.3
fmn-binding glutamate synthase family proteinSAV14893_000060Not AvailablePositive7502 - 908557270.6
pyruvate dehydrogenaseSAV14893_000070Not AvailablePositive9099 - 1086262377.4
hypothetical proteinSAV14893_000080Not AvailableNegative11085 - 1228442899.2
hypothetical proteinSAV14893_000090Not AvailablePositive12465 - 126385950.14
hypothetical proteinSAV14893_000100Not AvailableNegative12628 - 1296311826.8

Displaying genes 1 – 10 of 9908 in total

Metabolites

36 records
Metabolite IDMetabolite nameStructureCAS number
BASm0001885Tetra-mu3-sulfido-tetrairon(1+)Fe4S4Chemical structure of Tetra-mu3-sulfido-tetrairon(1+)Not available
Average351.62Da
Monoisotopic351.62748Da
BASm0004154(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthaleneC12H20Chemical structure of (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthaleneNot available
Average164.292Da
Monoisotopic164.156500644Da
BASm0004497avermitilolC15H26OChemical structure of avermitilolNot available
Average222.372Da
Monoisotopic222.198365457Da
BASm0014029(S)-3-Hydroxyisobutyric acidC19H35N5O6SeChemical structure of (S)-3-Hydroxyisobutyric acid26543-05-5
Average508.489Da
Monoisotopic509.175256Da
BASm0014033AmmoniaH3NChemical structure of Ammonia7664-41-7
Average17.0305Da
Monoisotopic17.026549101Da
BASm0014037Fumaric acidC4H4O4Chemical structure of Fumaric acid110-17-8
Average116.0722Da
Monoisotopic116.010958616Da
BASm0014038Malic acidC4H6O5Chemical structure of Malic acid97-67-6
Average134.0874Da
Monoisotopic134.021523302Da
BASm0014042Oxoglutaric acidC5H6O5Chemical structure of Oxoglutaric acid328-50-7
Average146.0981Da
Monoisotopic146.021523302Da
BASm00146054'-Deoleandrosyl-6,8a-seco-6,8a-deoxyaveC41H62O10Chemical structure of 4'-Deoleandrosyl-6,8a-seco-6,8a-deoxyaveNULL
Average714.937Da
Monoisotopic714.434298196Da
BASm0014757(5S,S)-5-methyl-3-(2-methylbutyl)furan-2(5H)-oneC10H16O2Chemical structure of (5S,S)-5-methyl-3-(2-methylbutyl)furan-2(5H)-oneNULL
Average168.236Da
Monoisotopic168.115029755Da

Displaying 1–10 of 36 metabolites

Health Effects

No health effects information available for this bacterium.