Streptococcus mitis

Gram-positiveCocciNon-motileFacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Lactobacillales

Family

Streptococcaceae

Genus

Streptococcus

Description

Streptococcus mitis is a Gram-positive, spherical-shaped microbe that thrives in mesophilic temperatures, is a chemoheterotroph, and can be found in all body sites in various species, including the oral cavity, respiratory tract, and gastrointestinal tract, and is a facultative anaerobe. As a Gram-positive microbe, Streptococcus mitis has a thick peptidoglycan layer in its cell wall, which provides it with a robust structure and allows it to retain the crystal violet stain during the Gram staining procedure, appearing purple under a microscope. Its spherical shape, also known as cocci, enables it to withstand various environmental pressures and interact with host cells. The mesophilic temperature preference of Streptococcus mitis indicates that it grows best in moderate temperatures, typically between 20-45°C, which is similar to the human body temperature. As a chemoheterotroph, Streptococcus mitis relies on external sources of energy and organic compounds to sustain its metabolic processes, which is why it can be found in various body sites where nutrients are abundant. Its ability to thrive in different environments, from the oral cavity to the gastrointestinal tract, makes it a versatile microbe. Being a facultative anaerobe, Streptococcus mitis can grow in the presence or absence of oxygen, allowing it to adapt to different conditions. In its natural habitat, Streptococcus mitis plays a crucial role in the oral microbiome, where it helps to break down complex carbohydrates and produce antimicrobial compounds that inhibit the growth of other microbes. Notably, Streptococcus mitis has been implicated in the development of endocarditis, a serious infection of the heart valves, particularly in individuals with pre-existing heart conditions, highlighting the importance of this microbe in human health and disease.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderLactobacillales
FamilyStreptococcaceae
GenusStreptococcus
SpeciesStreptococcus mitis
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Streptococcus mitis
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains-Pairs
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Gene Summary

Adenine Count

568025 bp

Thymine Count

578757 bp

Guanine Count

383454 bp

Cytosine Count

384962 bp

Genome Length

1915198 bp

Protein-coding Genes

1816 genes

Non-Coding Genes

85 genes

# of Chromosomes/Plasmids

23

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinTZ90_01886Not AvailablePositive1902438 - 19026538192.77
hypothetical proteinTZ90_01887Not AvailablePositive1902650 - 19029079967.07
hypothetical proteinTZ90_01888Not AvailablePositive1902954 - 190323510819.9
Putative replication proteinTZ90_01889Not AvailablePositive1903222 - 190407933483.1
Dnac proteinTZ90_01890Not AvailablePositive1904091 - 190493632268.4
hypothetical proteinTZ90_01891Not AvailablePositive1904942 - 19050975972.35
hypothetical proteinTZ90_01892Not AvailablePositive1905186 - 19053807519.83
Capsid proteinTZ90_01893Not AvailablePositive1905465 - 190631632598.6
hypothetical proteinTZ90_01894Not AvailablePositive1906327 - 190687821668.7
Hypothetical proteinTZ90_01895Not AvailablePositive1907241 - 190765116117.5

Displaying genes 11 – 20 of 43402 in total

Metabolites

93 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000403(S)-acetoinC4H8O2Chemical structure of (S)-acetoinNot available
Average88.1051Da
Monoisotopic88.0524295Da
BASm00006473-hydroxypropanoateC3H5O3Chemical structure of 3-hydroxypropanoateNot available
Average89.071Da
Monoisotopic89.0244176Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001279(6S)-5-methyl-5,6,7,8-tetrahydrofolateC20H23N7O6Chemical structure of (6S)-5-methyl-5,6,7,8-tetrahydrofolateNot available
Average457.4399Da
Monoisotopic457.1709815Da
BASm0001697(S)-4,5-dihydroxypentane-2,3-dioneC5H8O4Chemical structure of (S)-4,5-dihydroxypentane-2,3-dioneNot available
Average132.1146Da
Monoisotopic132.042258744Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001779orotateC5H3N2O4Chemical structure of orotateNot available
Average155.09Da
Monoisotopic155.0098302Da

Displaying 1–10 of 93 metabolites

Health Effects

Health ConditionRelationReference
Invasive streptococcal diseaseCausesPMC9328907
EndocarditisCausesPMC2828477
S. mitis meningitisCausesPMC2828477
EndocarditisCausesPMC3279804
PeritonitisCausesPMC7747055
Infective endocarditisCausesPMC3178606
Subacute infective endocarditisCausesPMC3178606

Displaying health effects 1 – 7 of 7 in total