Streptococcus mitis

Gram-positiveCocciNon-motileFacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Lactobacillales

Family

Streptococcaceae

Genus

Streptococcus

Description

Streptococcus mitis is a Gram-positive, spherical-shaped microbe that thrives in mesophilic temperatures, is a chemoheterotroph, and can be found in all body sites in various species, including the oral cavity, respiratory tract, and gastrointestinal tract, and is a facultative anaerobe. As a Gram-positive microbe, Streptococcus mitis has a thick peptidoglycan layer in its cell wall, which provides it with a robust structure and allows it to retain the crystal violet stain during the Gram staining procedure, appearing purple under a microscope. Its spherical shape, also known as cocci, enables it to withstand various environmental pressures and interact with host cells. The mesophilic temperature preference of Streptococcus mitis indicates that it grows best in moderate temperatures, typically between 20-45°C, which is similar to the human body temperature. As a chemoheterotroph, Streptococcus mitis relies on external sources of energy and organic compounds to sustain its metabolic processes, which is why it can be found in various body sites where nutrients are abundant. Its ability to thrive in different environments, from the oral cavity to the gastrointestinal tract, makes it a versatile microbe. Being a facultative anaerobe, Streptococcus mitis can grow in the presence or absence of oxygen, allowing it to adapt to different conditions. In its natural habitat, Streptococcus mitis plays a crucial role in the oral microbiome, where it helps to break down complex carbohydrates and produce antimicrobial compounds that inhibit the growth of other microbes. Notably, Streptococcus mitis has been implicated in the development of endocarditis, a serious infection of the heart valves, particularly in individuals with pre-existing heart conditions, highlighting the importance of this microbe in human health and disease.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderLactobacillales
FamilyStreptococcaceae
GenusStreptococcus
SpeciesStreptococcus mitis
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Streptococcus mitis
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains-Pairs
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Gene Summary

Adenine Count

606081 bp

Thymine Count

603931 bp

Guanine Count

407676 bp

Cytosine Count

397576 bp

Genome Length

2015269 bp

Protein-coding Genes

2181 genes

Non-Coding Genes

112 genes

# of Chromosomes/Plasmids

23

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
AttlNot AvailableNot AvailablePositive1895769 - 1895784Not Available
IntegraseTZ90_01877Not AvailableNegative1895849 - 189701544429.8
Pemk domain phage proteinTZ90_01878Not AvailableNegative1897846 - 189861029883.8
Hypothetical proteinTZ90_01879Not AvailableNegative1898799 - 189933819339.7
Dna binding/transcriptional regulatorTZ90_01880Not AvailableNegative1899568 - 190024526489.5
helix-turn-helix proteinTZ90_01881Not AvailablePositive1900404 - 19006047425.0
Putative antirepressorTZ90_01882Not AvailablePositive1900619 - 190122423399.7
hypothetical proteinTZ90_01883Not AvailablePositive1901236 - 190149610032.9
Hypothetical proteinTZ90_01884Not AvailablePositive1901808 - 190226017460.9
hypothetical proteinTZ90_01885Not AvailablePositive1902257 - 19024367311.67

Displaying genes 1 – 10 of 43402 in total

Metabolites

7 records
Metabolite IDMetabolite nameStructureCAS number
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da
BASm0001697(S)-4,5-dihydroxypentane-2,3-dioneC5H8O4Chemical structure of (S)-4,5-dihydroxypentane-2,3-dioneNot available
Average132.1146Da
Monoisotopic132.042258744Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0003276S-(5-deoxy-D-ribos-5-yl)-L-homocysteineC9H17NO6SChemical structure of S-(5-deoxy-D-ribos-5-yl)-L-homocysteine15912-98-8
Average267.299Da
Monoisotopic267.077658Da
BASm0003631(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylateC11H10O6Chemical structure of (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylateNot available
Average238.196Da
Monoisotopic238.0488352Da
BASm00037365-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylateC14H13O9Chemical structure of 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylateNot available
Average325.251Da
Monoisotopic325.057602738Da
BASm00037841,4-dihydroxy-2-naphthoyl-CoAC32H38N7O19P3SChemical structure of 1,4-dihydroxy-2-naphthoyl-CoANot available
Average949.67Da
Monoisotopic949.117798519Da

Displaying 1–7 of 7 metabolites

Health Effects

Health ConditionRelationReference
Invasive streptococcal diseaseCausesPMC9328907
EndocarditisCausesPMC2828477
S. mitis meningitisCausesPMC2828477
EndocarditisCausesPMC3279804
PeritonitisCausesPMC7747055
Infective endocarditisCausesPMC3178606
Subacute infective endocarditisCausesPMC3178606

Displaying health effects 1 – 7 of 7 in total