Haemophilus influenzae

Gram-negativeRodNon-motileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae is a Gram-negative, non-motile rod-shaped bacterium that typically exists in a host-associated habitat, exhibiting a facultative anaerobic oxygen requirement. This mesophilic organism thrives optimally at a temperature of 35°C. It is characterized by having two cellular membranes and possesses flagella, which may play a role in its biological interactions, despite its non-motile nature. Genetically, H. influenzae is notable for its multiple replicons, totaling six, which may contribute to its adaptability and survival in various environments. The organism is classified as free-living within its host-associated habitat, indicating it can exist independently while still being reliant on the host for certain nutrients or environmental conditions. The presence of multiple genome accessions, including NEBH00000000.1 and MZJQ00000000.1, suggests a genetic diversity that may facilitate its persistence and adaptability in host environments. Understanding the ecological role of Haemophilus influenzae provides insight into its interactions within microbial communities, particularly regarding its potential to influence host microbiomes and its contributions to microbial diversity in host-associated environments.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainNo strain

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Haemophilus influenzae strain NCTC13377 chromosome 1, complete

Gene Summary

Adenine Count

585509 bp

Thymine Count

585681 bp

Guanine Count

361405 bp

Cytosine Count

357874 bp

Genome Length

1890469 bp

Protein-coding Genes

1744 genes

Non-Coding Genes

167 genes

# of Chromosomes/Plasmids

6

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinDQL19_RS07190Not AvailableNegative1394024 - 139431111179.3
hypothetical proteinDQL19_RS07195Not AvailableNegative1394838 - 13950478168.98
Gp40DQL19_RS07200Not AvailablePositive1395061 - 13952346611.81
duf3037 domain-containing proteinDQL19_RS07205Not AvailableNegative1395727 - 139654231787.0
hipa family kinaseDQL19_RS07210Not AvailableNegative1396539 - 139727628730.2
Ci repressorDQL19_RS07215Not AvailableNegative1397346 - 139801124968.3
Regulatory protein croDQL19_RS07220Not AvailablePositive1398112 - 13983518581.25
Hypothetical proteinDQL19_RS07225Not AvailablePositive1398378 - 139867411402.6
Replication proteinDQL19_RS07230Not AvailableNegative1398733 - 13988946041.49
Uncharacterized phage-encoded proteinDQL19_RS07235Not AvailableNegative1398891 - 139919611517.8

Displaying genes 51 – 60 of 11180 in total

Metabolites

39 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm00007164-methylsulfanyl-2-oxobutanoateC5H7O3SChemical structure of 4-methylsulfanyl-2-oxobutanoateNot available
Average147.17Da
Monoisotopic147.012138839Da
BASm0000976enol-oxaloacetateC4H2O5Chemical structure of enol-oxaloacetateNot available
Average130.056Da
Monoisotopic129.9913203Da
BASm0001086scyllo-inososeC6H10O6Chemical structure of scyllo-inososeNot available
Average178.14Da
Monoisotopic178.0477381Da
BASm0001111keto-D-tagaturonateC6H9O7Chemical structure of keto-D-tagaturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001279(6S)-5-methyl-5,6,7,8-tetrahydrofolateC20H23N7O6Chemical structure of (6S)-5-methyl-5,6,7,8-tetrahydrofolateNot available
Average457.4399Da
Monoisotopic457.1709815Da
BASm0001774tetradecanoateC14H27O2Chemical structure of tetradecanoateNot available
Average227.363Da
Monoisotopic227.2011051Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da

Displaying 1–10 of 39 metabolites

Health Effects

Health ConditionRelationReference
Ear infection (otitis media)CausesPMC10964412
Lung infection (pneumonia)CausesPMC10964412
Exacerbations of chronic pulmonary diseases (e.g., chronic obstructive pulmonary disease, protracted bacterial bronchitis, and bronchiectasis)CausesPMC10964412
Ear infectionCausesPMC10964412
Otitis mediaCausesPMC10964412
Lung infectionCausesPMC10964412
PneumoniaCausesPMC10964412
Invasive diseaseCausesPMC10964412
MeningitisCausesPMC11116026
EncephalitisCausesPMC11116026

Displaying health effects 1 – 10 of 60 in total