Neisseria meningitidis

Gram-negativeCocciNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Neisseriales

Family

Neisseriaceae

Genus

Neisseria

Description

Neisseria meningitidis is a Gram-negative, non-motile coccus that typically arranges itself in pairs. This bacterium, classified as an aerobe, thrives optimally at a temperature of 35°C and is mesophilic in nature. N. meningitidis possesses two cellular membranes, characteristic of its Gram-negative classification, and exhibits a complex genomic structure with eight replicons, indicating a potentially intricate genomic architecture. This microbe is primarily host-associated, suggesting a strong dependence on host environments for its survival and reproduction, and it is classified as free-living within its ecological niche. Its cellular arrangement and absence of flagella suggest a lack of motility, which may influence its pathogenic mechanisms and host interactions. N. meningitidis is significant in microbiological studies due to its association with human hosts and its implications in public health. The specific genomic accessions provide a basis for further research into its genetic diversity and potential virulence factors. Understanding its unique traits, such as optimal growth conditions and cellular structure, can offer insights into its adaptation strategies and interactions within the host environment. This highlights the importance of N. meningitidis not only as a pathogen but also in the broader context of microbial ecology and host-associated dynamics.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassBetaproteobacteria
OrderNeisseriales
FamilyNeisseriaceae
GenusNeisseria
SpeciesNeisseria meningitidis
StrainNo strain

Profile

Physiology
Gram staining propertiesNegative
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Neisseria meningitidis
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementPairs
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Gene Summary

Adenine Count

500829 bp

Thymine Count

493977 bp

Guanine Count

537251 bp

Cytosine Count

543300 bp

Genome Length

2075515 bp

Protein-coding Genes

1935 genes

Non-Coding Genes

94 genes

# of Chromosomes/Plasmids

8

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
aspartate carbamoyltransferaseERS040961_01236P65615Positive1265521 - 126644134207.0
aspartate carbamoyltransferaseERS040961_01237Q9JWY6Positive1266451 - 126690916898.4
putative inner membrane proteinERS040961_01238Not AvailablePositive1266980 - 126763924462.7
putative peptidoglycan-binding periplasmic proteinERS040961_01239Not AvailableNegative1267702 - 126891945569.4
peptide deformylaseERS040961_01240A9M464Positive1269103 - 126960619116.2
methionyl-trna formyltransferaseERS040961_01241Q9JWY9Positive1269693 - 127061932904.9
16s rna methyltransferaseERS040961_01242Q9I7A9Positive1270698 - 127195746302.5
uncharacterised proteinERS040961_01243Not AvailablePositive1271923 - 127252221973.4
two-component system sensor kinaseERS040961_01244Q04850Positive1272522 - 127464276507.5
nitrogen assimilation regulatory protein ntrxERS040961_01245Q04849Positive1274635 - 127591246364.6

Displaying genes 1241 – 1250 of 17770 in total

Metabolites

116 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002543-hydroxy-2-methylpropanoateC4H7O3Chemical structure of 3-hydroxy-2-methylpropanoateNot available
Average103.098Da
Monoisotopic103.0400677Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da
BASm00005275-oxopentanoateC5H7O3Chemical structure of 5-oxopentanoateNot available
Average115.109Da
Monoisotopic115.040067665Da
BASm0000642S-adenosyl-4-methylsulfanyl-2-oxobutanoateC15H19N5O6SChemical structure of S-adenosyl-4-methylsulfanyl-2-oxobutanoateNot available
Average397.406Da
Monoisotopic397.105604055Da
BASm00008763-hydroxypyruvateC3H3O4Chemical structure of 3-hydroxypyruvateNot available
Average103.054Da
Monoisotopic103.003682157Da
BASm0000976enol-oxaloacetateC4H2O5Chemical structure of enol-oxaloacetateNot available
Average130.056Da
Monoisotopic129.9913203Da

Displaying 1–10 of 116 metabolites

Health Effects

Health ConditionRelationReference
MeningitisCausesPMC11116026
Invasive meningococcal disease (imd)CausesPMC12054086
Meningococcal meningitisCausesPMC1538595
Meningococcal septicemiaCausesPMC1538595
Meningococcal diseaseCausesPMC3125835
Bacterial meningitisCausesPMC3943661
Meningococcal diseaseCausesPMC3943661
Bacterial meningitisCausesPMC4364741
Severe sepsisCausesPMC4364741
Acute bacterial meningitisCausesPMC6306750

Displaying health effects 1 – 10 of 32 in total