Streptomyces clavuligerus

aerobic

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Kitasatosporales

Family

Streptomycetaceae

Genus

Streptomyces

Description

Streptomyces clavuligerus is a notable bacterium primarily found in soil environments. This species is an aerobic organism, requiring oxygen for its metabolic processes. It is categorized as mesophilic, thriving in moderate temperature ranges conducive to its growth and activity. One of the distinguishing features of S. clavuligerus is its true flagella, which enable motility and may play a role in its ecological interactions within the soil. Furthermore, the organism possesses a complex genomic structure characterized by 18 replicons, indicating a sophisticated genetic organization that may contribute to its adaptability and functionality in diverse soil conditions. S. clavuligerus is best known for its production of clavulanic acid, a β-lactamase inhibitor that has significant implications in antibiotic therapy, particularly in overcoming resistance in certain bacterial infections. This capability highlights the ecological role of S. clavuligerus within the soil microbiome, where it not only interacts with other microbial communities but also plays a part in the broader context of antibiotic resistance management. In summary, the presence of Streptomyces clavuligerus in soil environments, its aerobic nature, mesophilic temperature preference, motility through flagella, and notable genetic complexity underline its important ecological and biotechnological roles, particularly in the field of medicine.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderKitasatosporales
FamilyStreptomycetaceae
GenusStreptomyces
SpeciesStreptomyces clavuligerus
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeNot Available
MobilityNot Available
Flagellar presenceYes
Number of membranesNot Available
Image of Streptomyces clavuligerus
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsaerobic
Optimal temperatureNot Available
Temperature rangemesophilic
Habitatsoil
Biotic relationshipNot Available
Host(s)Not Available
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Gene Summary

Adenine Count

925966 bp

Thymine Count

918184 bp

Guanine Count

2448180 bp

Cytosine Count

2456261 bp

Genome Length

6748591 bp

Protein-coding Genes

5536 genes

Non-Coding Genes

95 genes

# of Chromosomes/Plasmids

18

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
aspartate carbamoyltransferase catalytic subunitGE265_03445B1W459Negative920498 - 92148435779.0
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase pyrrGE265_03450Q9KXR1Negative921659 - 92223420748.1
helix-turn-helix domain-containing proteinGE265_03455Not AvailablePositive922634 - 92313418132.5
transcription antitermination factor nusbGE265_03460Q827R4Negative923547 - 92397516245.2
elongation factor pGE265_03465Q827R5Negative923978 - 92454420601.6
m24 family metallopeptidaseGE265_03470P81535Negative924602 - 92570839155.8
aaa family atpaseGE265_03475Not AvailableNegative926410 - 92713525877.6
type ii 3-dehydroquinate dehydrataseGE265_03480A4FBE9Negative927160 - 92760015732.6
3-dehydroquinate synthaseGE265_03485Q827R8Negative927597 - 92869138228.9
shikimate kinaseGE265_03490Q827R9Negative928688 - 92917017411.6

Displaying genes 7851 – 7860 of 29387 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

22 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002002glyoxylateC2HO3Chemical structure of glyoxylateNot available
Average73.0275Da
Monoisotopic72.9925689Da
BASm0003389NADP(+)C21H25N7O17P3Chemical structure of NADP(+)Not available
Average740.386Da
Monoisotopic740.053624107Da
BASm0003563N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valineC14H24N3O6SChemical structure of N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valineNot available
Average362.42Da
Monoisotopic362.1391303Da
BASm0003686(2E,6E,10E)-geranylgeranyl diphosphateC20H33O7P2Chemical structure of (2E,6E,10E)-geranylgeranyl diphosphateNot available
Average447.426Da
Monoisotopic447.171798138Da
BASm0014202N-ButyrylglycineC6H11NO3Chemical structure of N-ButyrylglycineNULL
Average145.1564Da
Monoisotopic145.073893223Da
BASm0019999AllysineC6H11NO3Chemical structure of Allysine1962-83-0
Average145.1564Da
Monoisotopic145.0738932Da
BASm0034713EucalyptolC10H18OChemical structure of EucalyptolNULL
Average154.253Da
Monoisotopic154.1357652Da

Displaying 1–10 of 22 metabolites

Health Effects

No health effects information available for this bacterium.