Nocardia asteroides

Rodmicroaerophile

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Nocardiaceae

Genus

Nocardia

Description

Nocardia asteroides is a Gram-positive bacterium characterized by its rod shape and the presence of flagella. It is classified as a microaerophile, requiring lower levels of oxygen for growth compared to typical aerobic organisms. N. asteroides has two replicons, which are essential for its genetic replication and stability. This bacterium primarily affects Homo sapiens, leading to various health complications. Notably, it can cause pneumonia and more severe conditions such as disseminated nocardiosis, which refers to the spread of the infection throughout the body. Additionally, it is associated with actinomycetoma, a chronic infection that affects the skin and subcutaneous tissues. The health implications of N. asteroides highlight its significance as a pathogenic organism. Its ability to cause disseminated disease underscores the importance of understanding its ecological niche and interactions with human hosts. This bacterium's presence in the environment and its pathogenic potential can inform clinical practices and public health measures aimed at preventing infections, particularly in immunocompromised individuals. The accessions CP082844.1 and CP082845.1 provide genetic information that can further enhance our understanding of its biology and pathogenic mechanisms.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderMycobacteriales
FamilyNocardiaceae
GenusNocardia
SpeciesNocardia asteroides
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNot Available
Flagellar presenceYes
Number of membranesNot Available
Image of Nocardia asteroides
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsmicroaerophile
Optimal temperatureNot Available
Temperature rangeNot Available
HabitatNot Available
Biotic relationshipNot Available
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Nocardia asteroides , Complete Genome

Gene Summary

Adenine Count

1172318 bp

Thymine Count

1181754 bp

Guanine Count

2503892 bp

Cytosine Count

2499799 bp

Genome Length

7357763 bp

Protein-coding Genes

6573 genes

Non-Coding Genes

73 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
mbl fold metallo-hydrolaseK8O92_02340P50474Negative495247 - 49601126976.8
rhomboid family intramembrane serine proteaseK8O92_02345P9WM20Negative496080 - 49680524917.6
cysteine synthaseK8O92_02350P63874Negative496871 - 49783334478.3
moad/this family proteinK8O92_02355P0A647Negative497842 - 4981149488.34
m67 family metallopeptidaseK8O92_02360P64814Negative498148 - 49856715782.3
p1 family peptidaseK8O92_02365P9WM22Negative498720 - 49978435051.8
duf2017 domain-containing proteinK8O92_02370P53424Negative499846 - 50041520422.1
atp-dependent clp protease adapter clpsK8O92_02375Q5Z0W0Negative500438 - 50078812983.5
nicotinate phosphoribosyltransferaseK8O92_02380P9WJI9Positive500911 - 50222146106.1
isochorismatase family proteinK8O92_02385I6XD65Positive502453 - 50301919675.9

Displaying genes 481 – 490 of 6699 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4 records
Metabolite IDMetabolite nameStructureCAS number
BASm0014399Asterobactin AC34H55N7O13Chemical structure of Asterobactin ANULL
Average769.85Da
Monoisotopic769.385784859Da
BASm0014479Asterobactin CC37H61N7O13Chemical structure of Asterobactin CNULL
Average811.931Da
Monoisotopic811.432735052Da
BASm0015183Asterobactin BC35H57N7O13Chemical structure of Asterobactin BNULL
Average783.877Da
Monoisotopic783.401434923Da
BASm0039655Achromobacter xylosoxidans A8Not availableNot availableNot available

Displaying 1–4 of 4 metabolites

Health Effects

Health ConditionRelationReference
Disseminated nocardiosisCausesPMC9112502
Disseminated diseaseCausesPMC9112502
PneumoniaCausesPMC9112502
ActinomycetomaCausesPMC9780526
InfectionsCausesPMC12139244

Displaying health effects 1 – 5 of 5 in total