Paenibacillus larvae

RodMotilefacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Caryophanales

Family

Paenibacillaceae

Genus

Paenibacillus

Description

Paenibacillus larvae is a Gram-positive, rod-shaped bacterium that serves as the causative agent of American foulbrood (AFB) disease in honeybee colonies, particularly affecting Apis mellifera and other members of the Apinae and Anthophila groups. This bacterium is classified as a facultative anaerobe, indicating its ability to thrive in both aerobic and anaerobic environments. Its primary habitats include beehives, the digestive systems of bees, and hive debris, where it can persist and potentially infect young larvae. The bacterium possesses three replicons, which may play a role in its genetic adaptability and survival within its hosts. Paenibacillus larvae is mobile, allowing it to spread within the hive environment and potentially contribute to the transmission of AFB among bee populations. The health effects of this bacterium are significant; AFB is a serious bacterial disease that can lead to the collapse of honeybee colonies if not managed effectively. Understanding the ecological role of Paenibacillus larvae is crucial for beekeepers and researchers alike, as its presence within beehives can greatly impact bee health and colony viability. Effective management practices must be employed to control the spread of AFB and protect honeybee populations, highlighting the importance of monitoring for this pathogen in beekeeping operations.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderCaryophanales
FamilyPaenibacillaceae
GenusPaenibacillus
SpeciesPaenibacillus larvae
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityYes
Flagellar presenceNot Available
Number of membranesNot Available
Image of Paenibacillus larvae
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsfacultative anaerobe
Optimal temperatureNot Available
Temperature rangeNot Available
Habitatbeehives; gut; hive debris
Biotic relationshipNot Available
Host(s)Apinae, Apis mellifera, Anthophila
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Paenibacillus larvae , Complete Genome

Gene Summary

Adenine Count

1191508 bp

Thymine Count

1185714 bp

Guanine Count

946634 bp

Cytosine Count

944740 bp

Genome Length

4268596 bp

Protein-coding Genes

3896 genes

Non-Coding Genes

528 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
manganese transport system atp-binding protein mntbERICIV_01506O34338Positive1369693 - 137042426980.2
manganese transport system membrane protein mntcERICIV_01507O35024Positive1370478 - 137141033034.8
manganese transport system membrane protein mntdERICIV_01508O34500Positive1371407 - 137228831384.5
branched-chain amino acid transport system carrier protein brabERICIV_01509O34545Positive1372643 - 137396846584.4
hypothetical proteinERICIV_01510Not AvailablePositive1374399 - 137486917431.6
hypothetical proteinERICIV_01511Not AvailablePositive1374926 - 13751658918.4
hypothetical proteinERICIV_01512Not AvailableNegative1375301 - 137557310207.4
hypothetical proteinERICIV_01513Not AvailablePositive1375681 - 13759329882.47
hypothetical proteinERICIV_01514Not AvailablePositive1375969 - 13761607544.03
carboxymuconolactone decarboxylaseERICIV_01515O32166Positive1376234 - 137659012628.1

Displaying genes 1821 – 1830 of 4545 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4 records
Metabolite IDMetabolite nameStructureCAS number
BASm0016691Paenilarvin AC52H81N13O14Chemical structure of Paenilarvin ANULL
Average1112.297Da
Monoisotopic1111.60259434Da
BASm0016692Paenilarvin BC52H80N12O15Chemical structure of Paenilarvin BNULL
Average1113.281Da
Monoisotopic1112.586609924Da
BASm0016693Paenilarvin CC50H77N13O14Chemical structure of Paenilarvin CNULL
Average1084.243Da
Monoisotopic1083.571294211Da
BASm0016707SevadicinC23H26N4O4Chemical structure of SevadicinNULL
Average422.485Da
Monoisotopic422.195405333Da

Displaying 1–4 of 4 metabolites

Health Effects

Health ConditionRelationReference
American foulbroodCausesPMC10207761
American foulbrood (afb)CausesPMC10207761
American foulbroodCausesPMC12113734
American foulbroodCausesPMC5072193
American foulbrood (afb)CausesPMC5072193
American foulbrood (afb)CausesPMC5415181
American foulbrood (afb)CausesPMC7067210
American foulbroodCausesPMC7067210
Foulbrood diseaseCausesPMC7067210
AfbCausesPMC10539817

Displaying health effects 1 – 10 of 16 in total