Paenibacillus larvae

RodMotilefacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Caryophanales

Family

Paenibacillaceae

Genus

Paenibacillus

Description

Paenibacillus larvae is a Gram-positive, rod-shaped bacterium that serves as the causative agent of American foulbrood (AFB) disease in honeybee colonies, particularly affecting Apis mellifera and other members of the Apinae and Anthophila groups. This bacterium is classified as a facultative anaerobe, indicating its ability to thrive in both aerobic and anaerobic environments. Its primary habitats include beehives, the digestive systems of bees, and hive debris, where it can persist and potentially infect young larvae. The bacterium possesses three replicons, which may play a role in its genetic adaptability and survival within its hosts. Paenibacillus larvae is mobile, allowing it to spread within the hive environment and potentially contribute to the transmission of AFB among bee populations. The health effects of this bacterium are significant; AFB is a serious bacterial disease that can lead to the collapse of honeybee colonies if not managed effectively. Understanding the ecological role of Paenibacillus larvae is crucial for beekeepers and researchers alike, as its presence within beehives can greatly impact bee health and colony viability. Effective management practices must be employed to control the spread of AFB and protect honeybee populations, highlighting the importance of monitoring for this pathogen in beekeeping operations.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderCaryophanales
FamilyPaenibacillaceae
GenusPaenibacillus
SpeciesPaenibacillus larvae
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityYes
Flagellar presenceNot Available
Number of membranesNot Available
Image of Paenibacillus larvae
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsfacultative anaerobe
Optimal temperatureNot Available
Temperature rangeNot Available
Habitatbeehives; gut; hive debris
Biotic relationshipNot Available
Host(s)Apinae, Apis mellifera, Anthophila
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Paenibacillus larvae , Complete Genome

Gene Summary

Adenine Count

1191508 bp

Thymine Count

1185714 bp

Guanine Count

946634 bp

Cytosine Count

944740 bp

Genome Length

4268596 bp

Protein-coding Genes

3896 genes

Non-Coding Genes

528 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
abc-type mn/zn transport system, atpase componentERICIV_01456Q9XDA6Positive1325992 - 132676829373.6
abc-type mn2+/zn2+ transport system, permease componentERICIV_01457O34610Positive1326787 - 132760229267.6
cytochrome c-type biogenesis protein ccdaERICIV_01458P45706Positive1327642 - 132835226395.3
spore photoproduct lyase splgERICIV_01459P37956Negative1328380 - 132944141041.5
putative membrane proteinERICIV_01460P54478Positive1329710 - 133057631811.9
transcriptional regulator mntrERICIV_01461C5D492Positive1330670 - 133109816792.2
patatinERICIV_01462P54513Positive1331357 - 133231935804.4
hypothetical proteinERICIV_01463Not AvailableNegative1332400 - 133266610277.9
putative metal-dependent enzymeERICIV_01464P54515Negative1332663 - 133359835093.5
putative membrane proteinERICIV_01465P54516Positive1333796 - 133435320975.5

Displaying genes 1771 – 1780 of 4545 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4 records
Metabolite IDMetabolite nameStructureCAS number
BASm0016691Paenilarvin AC52H81N13O14Chemical structure of Paenilarvin ANULL
Average1112.297Da
Monoisotopic1111.60259434Da
BASm0016692Paenilarvin BC52H80N12O15Chemical structure of Paenilarvin BNULL
Average1113.281Da
Monoisotopic1112.586609924Da
BASm0016693Paenilarvin CC50H77N13O14Chemical structure of Paenilarvin CNULL
Average1084.243Da
Monoisotopic1083.571294211Da
BASm0016707SevadicinC23H26N4O4Chemical structure of SevadicinNULL
Average422.485Da
Monoisotopic422.195405333Da

Displaying 1–4 of 4 metabolites

Health Effects

Health ConditionRelationReference
American foulbroodCausesPMC10207761
American foulbrood (afb)CausesPMC10207761
American foulbroodCausesPMC12113734
American foulbroodCausesPMC5072193
American foulbrood (afb)CausesPMC5072193
American foulbrood (afb)CausesPMC5415181
American foulbrood (afb)CausesPMC7067210
American foulbroodCausesPMC7067210
Foulbrood diseaseCausesPMC7067210
AfbCausesPMC10539817

Displaying health effects 1 – 10 of 16 in total