Cutibacterium acnes strain T19834

Gram-positiveRodNon-motileAnaerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Propionibacteriales

Family

Propionibacteriaceae

Genus

Cutibacterium

Description

Cutibacterium acnes strain T19834 is a Gram-positive, anaerobic bacterium characterized by its rod shape and lack of mobility, as it possesses no flagella. This strain is part of the diverse microbial community associated with humans (Homo sapiens) and is free-living in its ecological niche. It thrives optimally at 37°C, which aligns with its mesophilic temperature range, making it well-suited to the human body. C. acnes strain T19834 is notable for its involvement in various health conditions. It is associated with acute bacterial meningitis and thoracic actinomycosis, as well as being a well-known contributor to common acne. Additionally, there are links to more severe health implications, such as epithelial ovarian cancer and infectious complications following procedures like vertebroplasty and kyphoplasty. The strain is nonsporulating and contains a single replicon, indicating a simple genomic structure. Its presence within human hosts highlights its potential role in both health and disease, emphasizing the importance of understanding its biotic relationships. The dual nature of C. acnes, as both a commensal organism and a pathogen, underscores the complexity of the human microbiome and suggests that its balance is crucial for maintaining health. Further research into this strain could provide insights into its pathogenic mechanisms and how it interacts with human hosts in various health contexts.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderPropionibacteriales
FamilyPropionibacteriaceae
GenusCutibacterium
SpeciesCutibacterium acnes
Strainstrain T19834

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Cutibacterium acnes strain T19834
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Cutibacterium acnes strain T19834

Gene Summary

Adenine Count

501568 bp

Thymine Count

479716 bp

Guanine Count

725688 bp

Cytosine Count

756711 bp

Genome Length

2463694 bp

Protein-coding Genes

2273 genes

Non-Coding Genes

52 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
sseb family proteinFD521_10665Not AvailableNegative2151172 - 215161515290.3
hypothetical proteinFD521_10670Not AvailablePositive2151733 - 215233221284.9
atp phosphoribosyltransferaseFD521_10675Not AvailableNegative2152394 - 215324830622.5
phosphoribosyl-atp diphosphataseFD521_10680Not AvailableNegative2153306 - 21535729928.83
nicotinamide mononucleotide transporterFD521_10685Not AvailableNegative2153639 - 215431024777.2
sco1664 family proteinFD521_10690Not AvailableNegative2154379 - 215515528076.5
duf3090 domain-containing proteinFD521_10695Not AvailableNegative2155176 - 215575721561.1
aldo/keto reductaseFD521_10700Not AvailablePositive2155960 - 215693434569.2
citrate synthaseFD521_10705Not AvailableNegative2156946 - 215825348522.1
m20/m25/m40 family metallo-hydrolaseFD521_10710Not AvailableNegative2158256 - 215962049036.1

Displaying genes 2021 – 2030 of 2325 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

32 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000305tetrathionateO6S4Chemical structure of tetrathionateNot available
Average224.24Da
Monoisotopic223.8588696Da
BASm0000399(S)-allantoinC4H6N4O3Chemical structure of (S)-allantoin97-59-6
Average158.1154Da
Monoisotopic158.0439901Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da
BASm00007164-methylsulfanyl-2-oxobutanoateC5H7O3SChemical structure of 4-methylsulfanyl-2-oxobutanoateNot available
Average147.17Da
Monoisotopic147.012138839Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm00011795-hydroxyisourateC5H4N4O4Chemical structure of 5-hydroxyisourateNot available
Average184.1097Da
Monoisotopic184.0232546Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002002glyoxylateC2HO3Chemical structure of glyoxylateNot available
Average73.0275Da
Monoisotopic72.9925689Da
BASm00021577-cyano-7-deazaguanineC7H5N5OChemical structure of 7-cyano-7-deazaguanineNot available
Average175.1475Da
Monoisotopic175.0494098Da

Displaying 1–10 of 32 metabolites

Health Effects

Health ConditionRelationReference
Acute bacterial meningitisCausesPMC6306750
Thoracic actinomycosisCausesPMC6956836
AcneCausesPMC7808774
Epithelial ovarian cancerCausesPMC10587687
AcneCausesPMC13314309
Infectious complications after vertebroplasty/kyphoplastyCausesPMC7379344
Common acneCausesPMC3388012
AcneCausesPMC8549750

Displaying health effects 1 – 8 of 8 in total