Cutibacterium acnes strain W65-307

Cutibacterium acnes strain W65-307 is a Gram-positive, anaerobic bacterium primarily associated with the host Homo sapiens. This rod-shaped microbe is non-motile and possesses flagella, although it does not utilize these for mobility. It thrives optimally at a temperature of 37°C, indicating its mesophilic nature, and it has a single replicon and membrane. This strain is known for its role in various health conditions, including acute bacterial meningitis, thoracic actinomycosis, and common acne. Additionally, it has been implicated in more serious conditions such as epithelial ovarian cancer and infectious complications following vertebroplasty or kyphoplasty. Despite its association with these health effects, Cutibacterium acnes is also recognized for its free-living biotic relationship, which suggests it can exist independently in the human body. The presence of Cutibacterium acnes in human hosts highlights its ecological role in the skin microbiome. While it is often linked to acne, its diverse pathogenic potential underscores the complexity of host-microbe interactions. Understanding the specific conditions under which this bacterium causes illness versus its role in maintaining skin health could provide insights into its dual nature in human health and disease. The strain's accession number is VBXR00000000.1, which catalogues its genetic information for further study.