Klebsiella pneumoniae strain EuSCAPE_ES252

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_ES252 is a significant human pathogen that exhibits a range of health effects, including bacteremia, urinary tract infections, pneumonia, and more. This Gram-negative bacterium is classified as a facultative anaerobe, which means it can thrive in both the presence and absence of oxygen. Its optimal growth temperature is 37°C, placing it in the mesophilic range, which is typical for many pathogens that infect warm-blooded hosts. The bacterium is characterized by its rod shape and the ability to form chains, pairs, and singles. Mobility is facilitated by the presence of flagella, which contribute to its motility. Klebsiella pneumoniae is free-living and has a complex biotic relationship with various hosts, including humans and several animal species such as Gallus gallus (chickens), Sus scrofa (pigs), and Canis lupus familiaris (dogs), among others. This strain has a single circular replicon and is nonsporulating, indicating that it does not form spores as a part of its reproductive strategy. Its dual membrane structure is typical for Gram-negative bacteria. The wide range of hosts and the extensive list of health conditions associated with Klebsiella pneumoniae strain EuSCAPE_ES252 underscore its adaptability and pathogenic potential. Understanding its ecological and biological traits is essential for developing effective treatment strategies and managing its impact on public health, particularly in settings where multidrug resistance may complicate infections.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_ES252

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_ES252
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_ES252 genome assembly,

Gene Summary

Adenine Count

1200844 bp

Thymine Count

1197352 bp

Guanine Count

1591721 bp

Cytosine Count

1585455 bp

Genome Length

5575372 bp

Protein-coding Genes

5004 genes

Non-Coding Genes

279 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Diguanylate cyclase domain proteinSAMEA3649568_02180Not AvailableNegative2384170 - 238518337649.8
AttlNot AvailableNot AvailablePositive2385315 - 2385336Not Available
IntegraseSAMEA3649568_02181Not AvailableNegative2385448 - 238643137205.8
Xre family transcriptional regulatorSAMEA3649568_02182Not AvailableNegative2386547 - 238684611174.4
Regulatory proteinSAMEA3649568_02183Not AvailablePositive2386967 - 238724510301.5
Hypothetical proteinSAMEA3649568_02184Not AvailablePositive2387266 - 23874848421.27
Hypothetical proteinSAMEA3649568_02185Not AvailablePositive2387500 - 238787714680.7
Hypothetical proteinSAMEA3649568_02186Not AvailablePositive2387893 - 238815610453.6
Hypothetical proteinSAMEA3649568_02187Not AvailablePositive2388234 - 23884588208.83
3'-5' exoribonucleaseSAMEA3649568_02188Not AvailablePositive2388455 - 238902121055.2

Displaying genes 1 – 10 of 5283 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total