Klebsiella pneumoniae strain EuSCAPE_ES273

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_ES273 is a Gram-negative, rod-shaped bacterium classified as a facultative anaerobe, indicating its ability to thrive in both aerobic and anaerobic environments. This organism is chemoheterotrophic, deriving its energy from organic compounds, and typically exhibits a mesophilic temperature range, with an optimal growth temperature of 37°C. Its cell arrangement can be observed in chains, pairs, and singles, and it possesses flagella, which contribute to its mobility. EuSCAPE_ES273 is notable for its diverse biotic relationships, being free-living and associated with various hosts including Homo sapiens, Gallus gallus, and multiple other metazoans and plants. This wide host range suggests a significant ecological versatility and potential for transmission across species. Clinically, K. pneumoniae strain EuSCAPE_ES273 is linked to a multitude of health effects, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Its pathogenicity in humans underscores its role as an opportunistic pathogen, particularly in immunocompromised individuals. The strain has been implicated in severe conditions such as neonatal sepsis and pyogenic liver abscesses, highlighting its potential for causing significant morbidity. The presence of a single replicon and two membranes characterizes its cellular structure, typical of Gram-negative bacteria. Understanding the ecological role and pathogenic potential of K. pneumoniae strain EuSCAPE_ES273 is essential for developing strategies to manage infections and prevent disease spread, particularly in healthcare settings where it poses a substantial risk.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_ES273

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_ES273
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_ES273 genome assembly,

Gene Summary

Adenine Count

1142278 bp

Thymine Count

1143980 bp

Guanine Count

1534820 bp

Cytosine Count

1536657 bp

Genome Length

5357735 bp

Protein-coding Genes

4821 genes

Non-Coding Genes

191 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
uncharacterised proteinSAMEA3649607_03845Not AvailablePositive4115850 - 411685138346.3
phage transcriptional regulator alpaSAMEA3649607_03846Not AvailablePositive4116959 - 41171959123.03
uncharacterised proteinSAMEA3649607_03847Not AvailablePositive4117319 - 411872553824.9
protein of uncharacterised function (duf3296)SAMEA3649607_03848Not AvailablePositive4118917 - 411953723696.2
uncharacterised proteinSAMEA3649607_03849Not AvailableNegative4119606 - 412025324525.0
uncharacterised proteinSAMEA3649607_03850Not AvailableNegative4120269 - 412102428991.3
oxidoreductaseSAMEA3649607_03851Not AvailableNegative4121054 - 412290167612.5
putative type i restriction-modification enzyme r subunitSAMEA3649607_03852Not AvailableNegative4122937 - 4125852111983.0
type i restriction modification dna specificity domain proteinSAMEA3649607_03853Not AvailableNegative4125911 - 412711345809.3
type i restriction enzymeSAMEA3649607_03854Not AvailableNegative4127113 - 412872059960.1

Displaying genes 3891 – 3900 of 5012 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total