Klebsiella pneumoniae strain EuSCAPE_HU065

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HU065 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, functioning as a chemoheterotroph. This strain typically exists in free-living environments but is notably associated with various hosts, including Homo sapiens, Gallus gallus, and several other vertebrates and invertebrates. Its optimal growth temperature is 37°C, placing it within the mesophilic range. The bacterium can be found in diverse arrangements, including chains, pairs, and singles, and possesses flagella, indicating mobility. It has a singular replicon and a double membrane structure, characteristic of its classification within the Enterobacteriaceae family. Klebsiella pneumoniae strain EuSCAPE_HU065 is known to cause a wide range of health issues, particularly in humans, where it has been implicated in conditions such as bacteremia, urinary tract infections, pneumonia, and sepsis. It is particularly noted for its role in severe infections like pyogenic liver abscesses and early onset neonatal sepsis, highlighting its significant pathogenicity. The ecological insight provided by this strain's wide host range and pathogenic potential underscores its adaptability and ability to thrive in various environments. This adaptability may contribute to its persistence in both clinical and environmental settings, posing challenges for infection control and management in healthcare.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HU065

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HU065
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HU065 genome assembly,

Gene Summary

Adenine Count

1082471 bp

Thymine Count

1076600 bp

Guanine Count

1442208 bp

Cytosine Count

1495693 bp

Genome Length

5096972 bp

Protein-coding Genes

4656 genes

Non-Coding Genes

135 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
putative carboxysome structural protein in ethanol utilizationSAMEA3538867_01960Not AvailableNegative2094741 - 209507611632.4
nadp-dependent malic enzymeSAMEA3538867_01961Not AvailableNegative2095295 - 209757482377.0
transaldolaseSAMEA3538867_01962Not AvailablePositive2097869 - 209882535457.8
transketolaseSAMEA3538867_01963Not AvailablePositive2098842 - 210083672201.7
protein of uncharacterised function (duf1176)SAMEA3538867_01964Not AvailableNegative2100826 - 210187238860.5
nudix hydrolase family protein yffhSAMEA3538867_01965Not AvailableNegative2101936 - 210253222158.3
pyridine nucleotide-disulfide oxidoreductase family proteinSAMEA3538867_01966Not AvailableNegative2102591 - 210457371461.0
aminoglycoside efflux pumpSAMEA3538867_01967Not AvailablePositive2104946 - 2108059112933.0
a glutathione-dependent thiol reductaseSAMEA3538867_01968Not AvailablePositive2108612 - 210896513477.3
n-succinyl-l,l-diaminopimelate desuccinylaseSAMEA3538867_01969Not AvailablePositive2108969 - 211009641372.6

Displaying genes 2021 – 2030 of 4791 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total