Klebsiella pneumoniae strain EuSCAPE_HU047

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HU047 is a Gram-negative, rod-shaped bacterium characterized as a facultative anaerobe and a chemoheterotroph. This strain can be found in various arrangements, including chains, pairs, and singles. Its optimal growth temperature is 37°C, and it thrives within a mesophilic temperature range. EuSCAPE_HU047 possesses flagella, which contributes to its motility. This bacterium is associated with a diverse range of hosts, including Homo sapiens, Gallus gallus, and several other animal species, indicating its adaptability in different biological contexts. The strain is known for its pathogenicity in humans, causing numerous health issues such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. These infections underline the strain's potential to significantly impact human health, particularly in vulnerable populations. Klebsiella pneumoniae strain EuSCAPE_HU047 is nonsporulating and has a single replicon with a double membrane structure, typical of Gram-negative bacteria. Its free-living biotic relationship suggests that it can exist independently in certain environments, although it is also capable of being pathogenic in hosts. The ecological insight derived from these traits highlights the strain's role in both environmental and clinical settings, illustrating the dual nature of Klebsiella pneumoniae as both a commensal organism and a significant human pathogen. The strain’s versatility and ability to thrive in various host species enhance its potential for transmission and pathogenic impact in human populations.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HU047

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HU047
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HU047 genome assembly,

Gene Summary

Adenine Count

1254372 bp

Thymine Count

1251183 bp

Guanine Count

1647902 bp

Cytosine Count

1633175 bp

Genome Length

5786632 bp

Protein-coding Genes

5050 genes

Non-Coding Genes

324 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
benzoate dioxygenase, ferredoxin reductase componentSAMEA3538828_02459Not AvailableNegative2657662 - 265867836750.0
benzoate 1,2-dioxygenase subunit betaSAMEA3538828_02460Not AvailableNegative2658688 - 265917319332.6
2-chlorobenzoate 1,2-dioxygenase, alpha subunitSAMEA3538828_02461Not AvailableNegative2659173 - 266055552476.7
catechol 1,2-dioxygenaseSAMEA3538828_02462Not AvailableNegative2660665 - 266159134290.3
muconolactone isomeraseSAMEA3538828_02463Not AvailableNegative2661658 - 266194811212.5
l-ala-d/l-glu epimeraseSAMEA3538828_02464Not AvailableNegative2661968 - 266308638962.9
pca regulon regulatory protein pcarSAMEA3538828_02465Not AvailablePositive2663340 - 266413728310.6
methyl viologen resistance protein smvaSAMEA3538828_02466Not AvailableNegative2664132 - 266563151621.3
transcriptional regulator tetr familySAMEA3538828_02467Not AvailablePositive2665794 - 266633019945.2
nitrate/nitrite transport protein naruSAMEA3538828_02468Not AvailablePositive2666505 - 266788749510.5

Displaying genes 2631 – 2640 of 5374 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total