Klebsiella pneumoniae strain EuSCAPE_HU013

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HU013 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, utilizing chemoheterotrophic energy sources. It is capable of mobility, possessing flagella, and typically arranges itself in chains, pairs, or singles. This strain thrives optimally at 37°C, falling within the mesophilic temperature range. Ecologically, EuSCAPE_HU013 is primarily host-associated, indicating a significant relationship with various hosts, including Homo sapiens (humans) and a variety of other organisms such as Gallus gallus (chickens), Danio rerio (zebrafish), and several species of mammals and birds. This diverse host range underscores its adaptability and potential for transmission across different species. In terms of health impacts, Klebsiella pneumoniae strain EuSCAPE_HU013 is associated with a wide array of serious infections, including bacteremia, urinary tract infections, pneumonia, and meningitis, among others. The range of infections it can cause suggests a notable pathogenicity in humans, contributing to significant morbidity and, in some cases, mortality. The presence of only one replicon and two membranes in its cellular structure indicates its classification as a typical Gram-negative bacterium, which may influence its interactions with host immune systems and antibiotic resistance mechanisms. Overall, the versatility of Klebsiella pneumoniae strain EuSCAPE_HU013 in thriving in diverse habitats and its pathogenic potential highlights the need for ongoing surveillance and research to understand its role in both human health and environmental ecosystems.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HU013

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HU013
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HU013 genome assembly,

Gene Summary

Adenine Count

1222852 bp

Thymine Count

1220426 bp

Guanine Count

1628231 bp

Cytosine Count

1624553 bp

Genome Length

5696062 bp

Protein-coding Genes

5163 genes

Non-Coding Genes

233 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
putative resolvaseSAMEA3538765_05034Not AvailablePositive5358881 - 535949522262.9
uncharacterised proteinSAMEA3538765_05035Not AvailablePositive5359988 - 53601917594.31
bifunctional purine biosynthesis protein purhSAMEA3538765_05036Not AvailablePositive5360196 - 536178557193.2
phosphoribosylamine--glycine ligaseSAMEA3538765_05037Not AvailablePositive5361801 - 536309645926.6
response regulator of zinc sigma-54-dependent two-component systemSAMEA3538765_05038Not AvailableNegative5363086 - 536441748766.8
sensor protein of zinc sigma-54-dependent two-component systemSAMEA3538765_05039Not AvailableNegative5364404 - 536579851343.3
zinc resistance-associated proteinSAMEA3538765_05040Not AvailablePositive5366058 - 536649515996.9
lipoproteinSAMEA3538765_05041Not AvailableNegative5366499 - 536719425901.5
dna-binding protein hu-alphaSAMEA3538765_05042Not AvailableNegative5367207 - 53674799477.42
protein of uncharacterised function (duf416)SAMEA3538765_05043Not AvailableNegative5367666 - 536825622640.0

Displaying genes 5041 – 5050 of 5396 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total