Klebsiella pneumoniae strain EuSCAPE_IT333

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT333 is a significant human pathogen classified as a Gram-negative, rod-shaped bacterium with a facultative anaerobic metabolism, utilizing chemoheterotrophic energy sources. Its cellular arrangement can be observed in chains, pairs, and singles, and it possesses flagella, indicating mobility. This strain is mesophilic, with an optimal growth temperature of 37°C. K. pneumoniae EuSCAPE_IT333 is associated with various hosts, including Homo sapiens, Gallus gallus, and multiple other metazoans and plants. This broad host range highlights its ecological versatility and potential interactions within diverse biological communities. The strain has been implicated in numerous health issues, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Its pathogenicity in humans is particularly concerning, as it can lead to severe conditions such as sepsis and neonatal sepsis. The bacterium is nonsporulating and has a complex cellular structure with two membranes and a single replicon. Its ability to thrive in host-associated environments suggests it can exploit resources available in its hosts, contributing to its pathogenicity and survival. Understanding the traits and behaviors of K. pneumoniae strain EuSCAPE_IT333 provides insights into its role in human health as well as its ecological interactions. Its adaptability across various hosts underscores the importance of surveillance and control measures in managing infections and understanding its epidemiology in both clinical and environmental contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT333

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT333
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT333 genome assembly,

Gene Summary

Adenine Count

1218800 bp

Thymine Count

1210111 bp

Guanine Count

1619627 bp

Cytosine Count

1623821 bp

Genome Length

5672359 bp

Protein-coding Genes

5076 genes

Non-Coding Genes

406 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
glycosyltransferaseSAMEA3538701_00021Not AvailableNegative21457 - 2335273057.1
teichoic acid export atp-binding protein taghSAMEA3538701_00022Not AvailableNegative23368 - 2410827433.6
abc transporter permeaseSAMEA3538701_00023Not AvailableNegative24108 - 2487529578.2
dtdp-glucose 4,6-dehydrataseSAMEA3538701_00024Not AvailablePositive25919 - 2692337587.7
uncharacterised proteinSAMEA3538701_00025Not AvailableNegative27923 - 2950058092.2
uncharacterised proteinSAMEA3538701_00026Not AvailablePositive29769 - 3080340256.0
putative glycosyl transferaseSAMEA3538701_00027Not AvailableNegative32457 - 3344937812.9
putative o-antigen transporterSAMEA3538701_00028Not AvailableNegative33446 - 3468145511.5
uridine diphosphate galacturonate 4-epimeraseSAMEA3538701_00029Not AvailableNegative35249 - 3625037782.0
udp-glucose dehydrogenaseSAMEA3538701_00030Not AvailableNegative36444 - 3761043465.0

Displaying genes 391 – 400 of 5482 in total

Metabolites

1305 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000272(E)-4-coumarateC9H7O3Chemical structure of (E)-4-coumarateNot available
Average163.1501Da
Monoisotopic163.0395191Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000399(S)-allantoinC4H6N4O3Chemical structure of (S)-allantoin97-59-6
Average158.1154Da
Monoisotopic158.0439901Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da

Displaying 1–10 of 1305 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total