Klebsiella pneumoniae strain EuSCAPE_IT330

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT330 is a Gram-negative, facultative anaerobic, rod-shaped bacterium that typically exists in host-associated environments. It is classified as a chemoheterotroph, utilizing organic compounds for energy. This strain exhibits a range of cellular arrangements, including chains, pairs, and singles, and possesses flagella, which contribute to its mobility. EuSCAPE_IT330 is mesophilic, with an optimal growth temperature of 37°C, making it well-suited to thrive in the human body, as well as various other hosts, including Gallus gallus (chickens), Danio rerio (zebrafish), and multiple mammalian species. It is free-living but also exhibits significant pathogenicity in humans, causing a multitude of serious health conditions. The strain is implicated in bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections, among others. The broad range of hosts and the extensive list of associated health effects highlight the ecological versatility and potential impact of Klebsiella pneumoniae strain EuSCAPE_IT330. Its ability to cause severe infections, such as sepsis and meningitis, underscores the importance of monitoring this bacterium in clinical settings and the need for effective infection control measures. This strain exemplifies the complexities of microbial-host interactions and the potential for opportunistic pathogens to exploit various ecological niches within host organisms.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT330

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT330
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT330 genome assembly,

Gene Summary

Adenine Count

1218505 bp

Thymine Count

1216253 bp

Guanine Count

1620874 bp

Cytosine Count

1624170 bp

Genome Length

5679802 bp

Protein-coding Genes

5093 genes

Non-Coding Genes

410 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
3-oxoacyl-acp reductaseSAMEA3538698_01897Not AvailableNegative1982228 - 198298927625.3
putative l-xylulose kinaseSAMEA3538698_01898Not AvailableNegative1983001 - 198453957194.0
glycerol uptake operon antiterminator regulatory proteinSAMEA3538698_01899Not AvailableNegative1984560 - 198511120396.0
putative phospho-2-dehydro-3-deoxyheptonate aldolaseSAMEA3538698_01900Not AvailableNegative1985126 - 198591728214.8
zn-finger proteinSAMEA3538698_01901Not AvailableNegative1986431 - 19866829133.67
dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complexSAMEA3538698_01902Not AvailableNegative1986859 - 198825649543.6
dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexSAMEA3538698_01903Not AvailableNegative1988246 - 198978154294.1
acetoin:dcpip oxidoreductase beta subunitSAMEA3538698_01904Not AvailableNegative1989785 - 199080436560.1
acetoin dehydrogenase e1 component alpha-subunitSAMEA3538698_01905Not AvailableNegative1990816 - 199177534018.4
transcriptional regulator acokSAMEA3538698_01906Not AvailablePositive1992028 - 1994793104213.0

Displaying genes 2151 – 2160 of 5503 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total