Klebsiella pneumoniae strain EuSCAPE_IT375

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT375 is a Gram-negative, rod-shaped bacterium classified as a facultative anaerobe. It is characterized by its ability to thrive in various environments, including host-associated habitats, and exhibits mobility due to the presence of flagella. The strain is mesophilic, with an optimal growth temperature of 37°C, making it well-suited for growth in the human body. As a chemoheterotroph, K. pneumoniae EuSCAPE_IT375 derives energy from organic compounds. It typically arranges itself in chains, pairs, and singles, reflecting a versatile lifestyle that allows it to adapt to different ecological niches. This strain has a single replicon and is surrounded by two membranes, a characteristic feature of Gram-negative bacteria. The bacterium is known for its pathogenicity in humans and can cause a variety of serious health issues, including bacteremia, urinary tract infections, pneumonia, and sepsis. It has also been implicated in more severe conditions such as liver abscesses and meningitis. The extensive list of hosts includes not only Homo sapiens but also various animals, indicating a broad ecological impact and potential for zoonotic transmission. Given its capacity to cause a wide range of infections, K. pneumoniae strain EuSCAPE_IT375 underscores the importance of monitoring antibiotic resistance and understanding its role in human and animal health. The strain's adaptability to diverse hosts may contribute to its persistence and pathogenic potential in both clinical and environmental contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT375

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT375
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT375 genome assembly,

Gene Summary

Adenine Count

1199676 bp

Thymine Count

1202478 bp

Guanine Count

1583255 bp

Cytosine Count

1589472 bp

Genome Length

5574881 bp

Protein-coding Genes

5100 genes

Non-Coding Genes

175 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
drug/metabolite transporter permeaseSAMEA3538790_05125Not AvailableNegative5421384 - 542225330774.4
lipoprotein nlpcSAMEA3538790_05126Not AvailablePositive5422771 - 542323217648.8
outer membrane pore protein eSAMEA3538790_05127Not AvailableNegative5423277 - 542432938725.9
glutamate 5-kinaseSAMEA3538790_05128Not AvailablePositive5424619 - 542572239119.1
gamma-glutamyl phosphate reductaseSAMEA3538790_05129Not AvailablePositive5425733 - 542698644817.9
Trna-thrNot AvailableNot AvailablePositive5427100 - 5427175Not Available
phage integrase family site-specific recombinaseSAMEA3538790_05131Not AvailablePositive5427342 - 542857746340.1
tranposaseSAMEA3538790_05132Not AvailableNegative5428756 - 542946027896.9
putative abc transporter, permease proteinSAMEA3538790_05133Not AvailablePositive5429884 - 543102941191.3
abc transporter, atp-binding proteinSAMEA3538790_05134Not AvailablePositive5431035 - 543182628059.2

Displaying genes 5131 – 5140 of 5275 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total