Klebsiella pneumoniae strain EuSCAPE_IT185

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT185 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, utilizing a chemoheterotrophic energy source. This strain is characterized by its ability to form chains, pairs, and singles, displaying mobility due to the presence of flagella. EuSCAPE_IT185 thrives optimally at a temperature of 37°C, indicative of its mesophilic nature. This bacterium is primarily host-associated and has been identified in a wide range of hosts, including Homo sapiens (humans), Gallus gallus (chickens), and various other metazoans and vertebrates. Its biotic relationship is categorized as free-living, suggesting potential ecological interactions within diverse environments. Klebsiella pneumoniae strain EuSCAPE_IT185 is significant due to its pathogenicity in humans, where it has been implicated in numerous health complications, including bacteremia, urinary tract infections, pneumonia, and various forms of abscesses. The strain is associated with severe conditions such as neonatal sepsis, septicemia, and pyogenic liver abscesses. Its ability to cause infections in multiple anatomical sites underlines its clinical relevance. The presence of EuSCAPE_IT185 in a variety of hosts emphasizes the potential for cross-species transmission and adaptation, highlighting its ecological versatility. This adaptability may contribute to its persistence in both human and animal health contexts, reinforcing the importance of monitoring Klebsiella pneumoniae strains in clinical and environmental settings to mitigate their impact on health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT185

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT185
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT185 genome assembly,

Gene Summary

Adenine Count

1198215 bp

Thymine Count

1189746 bp

Guanine Count

1592285 bp

Cytosine Count

1597205 bp

Genome Length

5577451 bp

Protein-coding Genes

5061 genes

Non-Coding Genes

180 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
gluconate 2-dehydrogenase, flavoprotein subunitSAMEA3515214_00023Not AvailablePositive26341 - 2812565392.3
gluconate 2-dehydrogenaseSAMEA3515214_00024Not AvailablePositive28139 - 2947647840.2
abc transporter atpase ccmaSAMEA3515214_00025Not AvailablePositive29560 - 3018322417.2
heme exporter permease componentSAMEA3515214_00026Not AvailablePositive30180 - 3083922936.4
cytochrome c-type biogenesis protein ccmc, putative heme lyase for ccmeSAMEA3515214_00027Not AvailablePositive30889 - 3162627428.4
cytochrome c-type biogenesis protein ccmd, interacts with ccmceSAMEA3515214_00028Not AvailablePositive31623 - 318538394.03
cytochrome c-type biogenesis protein ccme, heme chaperoneSAMEA3515214_00029Not AvailablePositive31837 - 3229516767.2
cytochrome c heme lyase subunit ccmfSAMEA3515214_00030Not AvailablePositive32292 - 3424472360.1
cytochrome c-type biogenesis protein ccmg/dsbe, thiol:disulfide oxidoreductaseSAMEA3515214_00031Not AvailablePositive34241 - 3479521021.5
cytochrome c heme lyase subunit ccmlSAMEA3515214_00032Not AvailablePositive34795 - 3525317051.8

Displaying genes 141 – 150 of 5241 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total