Klebsiella pneumoniae strain EuSCAPE_IT172

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT172 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, relying on chemoheterotrophy for energy. This strain typically exists in various arrangements, including chains, pairs, and singles, and is motile due to the presence of flagella. It thrives optimally at 37°C, within the mesophilic temperature range, and possesses a single replicon and two membranes. EuSCAPE_IT172 is associated with numerous hosts, including Homo sapiens, Gallus gallus, and various other vertebrates and invertebrates, suggesting a broad ecological niche. It is characterized as free-living and exhibits significant pathogenicity in humans, being implicated in a wide range of health issues such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The strain is notably responsible for severe infections like pyogenic liver abscesses and neonatal sepsis. In terms of its ecological impact, Klebsiella pneumoniae's ability to inhabit diverse hosts alongside its pathogenic potential highlights its role in both environmental and clinical settings. The strain's adaptability to various environments and hosts may contribute to its persistence and transmission, emphasizing the importance of monitoring such bacteria in public health contexts. The presence of this bacterium in multiple species underlines its significance in zoonotic disease dynamics and the need for further research into its epidemiology and resistance mechanisms.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT172

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT172
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT172 genome assembly,

Gene Summary

Adenine Count

1186341 bp

Thymine Count

1179367 bp

Guanine Count

1581438 bp

Cytosine Count

1585056 bp

Genome Length

5532202 bp

Protein-coding Genes

4986 genes

Non-Coding Genes

346 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hflk proteinSAMEA3515201_03429Not AvailablePositive3584162 - 358542445570.5
hflc proteinSAMEA3515201_03430Not AvailablePositive3585427 - 358643137616.9
uncharacterised proteinSAMEA3515201_03431Not AvailableNegative3586514 - 35868079676.8
inner membrane protein yjetSAMEA3515201_03432Not AvailablePositive3587027 - 35872247186.22
adenylosuccinate synthetaseSAMEA3515201_03433Not AvailablePositive3587327 - 358862547168.6
nitrite-sensitive transcriptional repressor nsrrSAMEA3515201_03434Not AvailablePositive3588776 - 358920115650.2
3'-to-5' exoribonuclease rnase rSAMEA3515201_03435Not AvailablePositive3589238 - 359167091821.0
23s rrna (guanosine-2'-o-)-methyltransferaseSAMEA3515201_03436Not AvailablePositive3591752 - 359248326535.3
isovaleryl coa dehydrogenaseSAMEA3515201_03437Not AvailablePositive3592609 - 359424660638.2
membrane proteinSAMEA3515201_03438Not AvailableNegative3594237 - 35945129955.61

Displaying genes 3601 – 3610 of 5332 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total