Klebsiella pneumoniae strain EuSCAPE_IT166

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT166 is a Gram-negative, rod-shaped bacterium that typically exists in host-associated environments. As a facultative anaerobe, it can adapt to varying oxygen levels while primarily obtaining energy as a chemoheterotroph. This strain is known to form chains, pairs, and singles, reflecting its diverse cell arrangement capabilities. Optimal growth occurs at 37°C, within a mesophilic temperature range. This strain possesses flagella, indicating mobility, and has a unique biotic relationship characterized as free-living. It has one replicon and is composed of two membranes, typical of Gram-negative bacteria. EuSCAPE_IT166 has been associated with a wide range of hosts, including Homo sapiens, Gallus gallus, and various other Metazoa, indicating its ability to infect multiple species. Clinically, Klebsiella pneumoniae strain EuSCAPE_IT166 is associated with serious health effects in humans, such as bacteremia, urinary tract infections, pneumonia, and various forms of sepsis. Its pathogenicity is significant, leading to complications like liver abscesses and meningitis. The diversity of hosts and the extensive list of health complications linked to this strain highlight its ecological adaptability and potential impact on public health. The ability of EuSCAPE_IT166 to thrive in both human and animal hosts underscores its role in the microbiome and potential for zoonotic transmission, emphasizing the importance of monitoring this pathogen in clinical and environmental contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT166

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT166
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT166 genome assembly,

Gene Summary

Adenine Count

1214456 bp

Thymine Count

1214644 bp

Guanine Count

1632729 bp

Cytosine Count

1611326 bp

Genome Length

5673155 bp

Protein-coding Genes

5068 genes

Non-Coding Genes

411 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Lysr family transcriptional regulatorSAMEA3515195_00449Not AvailablePositive457822 - 45870633132.1
Nucleotidyltransferase domain-containing proteinSAMEA3515195_00450Not AvailablePositive458831 - 45963130046.4
AttlNot AvailableNot AvailablePositive459906 - 459952Not Available
Hypothetical proteinSAMEA3515195_00451Not AvailableNegative460066 - 46161660292.0
Site-specific integraseSAMEA3515195_00452Not AvailableNegative461613 - 46263838585.7
Repressor proteinSAMEA3515195_00453Not AvailableNegative462641 - 46304514825.8
Rha family transcriptional regulatorSAMEA3515195_00454Not AvailablePositive463429 - 4636357893.57
Regulatory protein ciiSAMEA3515195_00455Not AvailablePositive463668 - 46417718263.1
Hypothetical proteinSAMEA3515195_00456Not AvailablePositive464349 - 46468712774.5
Hypothetical proteinSAMEA3515195_00457Not AvailablePositive464755 - 4649888623.24

Displaying genes 1 – 10 of 5479 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
MeningitisCausesPMC13168211
Neonatal sepsisCausesPMC13168211
PneumoniaCausesPMC13253921
Urinary tract infectionsCausesPMC13253921
BacteremiaCausesPMC13253921
Neonatal sepsisCausesPMC13253921
Pyogenic liver abscessCausesPMC13253921
MeningitisCausesPMC13253921
Early onset neonatal sepsisCausesPMC4560869
Pyogenic liver abscessCausesPMC7332619

Displaying health effects 21 – 30 of 53 in total