Klebsiella pneumoniae strain EuSCAPE_IT166

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT166 is a Gram-negative, rod-shaped bacterium that typically exists in host-associated environments. As a facultative anaerobe, it can adapt to varying oxygen levels while primarily obtaining energy as a chemoheterotroph. This strain is known to form chains, pairs, and singles, reflecting its diverse cell arrangement capabilities. Optimal growth occurs at 37°C, within a mesophilic temperature range. This strain possesses flagella, indicating mobility, and has a unique biotic relationship characterized as free-living. It has one replicon and is composed of two membranes, typical of Gram-negative bacteria. EuSCAPE_IT166 has been associated with a wide range of hosts, including Homo sapiens, Gallus gallus, and various other Metazoa, indicating its ability to infect multiple species. Clinically, Klebsiella pneumoniae strain EuSCAPE_IT166 is associated with serious health effects in humans, such as bacteremia, urinary tract infections, pneumonia, and various forms of sepsis. Its pathogenicity is significant, leading to complications like liver abscesses and meningitis. The diversity of hosts and the extensive list of health complications linked to this strain highlight its ecological adaptability and potential impact on public health. The ability of EuSCAPE_IT166 to thrive in both human and animal hosts underscores its role in the microbiome and potential for zoonotic transmission, emphasizing the importance of monitoring this pathogen in clinical and environmental contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT166

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT166
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT166 genome assembly,

Gene Summary

Adenine Count

1214456 bp

Thymine Count

1214644 bp

Guanine Count

1632729 bp

Cytosine Count

1611326 bp

Genome Length

5673155 bp

Protein-coding Genes

5068 genes

Non-Coding Genes

411 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
transcriptional regulatorSAMEA3515195_05369Not AvailableNegative5575134 - 557600331330.0
phosphonate dehydrogenase (nad-dependent phosphite dehydrogenase)SAMEA3515195_05370Not AvailableNegative5575997 - 557700736399.1
phosphate abc transporter permeaseSAMEA3515195_05371Not AvailableNegative5577016 - 557784329460.7
abc-type phosphate/phosphonate transport system, periplasmic componentSAMEA3515195_05372Not AvailableNegative5577852 - 557871531321.6
atp-binding protein of phosphonate abc transporterSAMEA3515195_05373Not AvailableNegative5578712 - 557953929711.0
transposaseSAMEA3515195_05374Not AvailablePositive5579881 - 558020112404.2
putative kinaseSAMEA3515195_05375Not AvailableNegative5580932 - 5584000109252.0
nitrite transporterSAMEA3515195_05376Not AvailableNegative5583997 - 558437714249.2
arsr family transcriptional regulatorSAMEA3515195_05377Not AvailableNegative5584387 - 558486917603.1
alkanesulfonate abc transporter permeaseSAMEA3515195_05378Not AvailableNegative5585050 - 558551417699.2

Displaying genes 5381 – 5390 of 5479 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total