Klebsiella pneumoniae strain EuSCAPE_IT223

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT223 is a Gram-negative, rod-shaped, and facultative anaerobic bacterium that thrives as a chemoheterotroph, primarily associated with hosts, including Homo sapiens and various other animals such as Gallus gallus and Sus scrofa. This strain is characterized by its ability to form chains, pairs, and singles, and it possesses flagella, which contribute to its mobility. The optimal growth temperature for EuSCAPE_IT223 is 37°C, placing it within a mesophilic temperature range. This temperature preference aligns with its pathogenicity in humans, where it is known to cause a variety of serious infections, including bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The diverse list of health effects underscores its role as a significant human pathogen, particularly in immunocompromised individuals. Klebsiella pneumoniae strain EuSCAPE_IT223 is nonsporulating and exhibits a biotic relationship as a free-living organism. It contains a single replicon and two membranes, typical of Gram-negative bacteria. From an ecological perspective, the widespread presence of Klebsiella pneumoniae in various animal hosts suggests a complex interaction within ecosystems, where it may serve both as a commensal organism and a potential pathogen. Its ability to cause infections across a wide range of hosts emphasizes the importance of understanding its ecology and transmission dynamics, particularly in relation to public health and infection control measures.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT223

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT223
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT223 genome assembly,

Gene Summary

Adenine Count

1212407 bp

Thymine Count

1209554 bp

Guanine Count

1608571 bp

Cytosine Count

1598434 bp

Genome Length

5628966 bp

Protein-coding Genes

5090 genes

Non-Coding Genes

299 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
outer membrane protein/protective antigen oma87SAMEA3515251_04199Not AvailableNegative4444811 - 444594442200.3
lipoproteinSAMEA3515251_04200Not AvailableNegative4445941 - 444700238528.8
phosphatase yidaSAMEA3515251_04201Not AvailableNegative4447173 - 444798529544.6
dna gyrase subunit bSAMEA3515251_04202Not AvailableNegative4448186 - 445060090092.3
dna recombination and repair protein recfSAMEA3515251_04203Not AvailableNegative4450629 - 445170240575.6
dna polymerase iii subunit betaSAMEA3515251_04204Not AvailableNegative4451849 - 445294940483.9
chromosomal replication initiator protein dnaaSAMEA3515251_04205Not AvailableNegative4452954 - 445435752369.6
rnase pSAMEA3515251_04206Not AvailableNegative4455171 - 44553687282.6
membrane protein insertaseSAMEA3515251_04207Not AvailablePositive4455718 - 445736461467.5
gtpase and trna-u34 5-formylation enzyme trmeSAMEA3515251_04208Not AvailablePositive4457559 - 445892349072.6

Displaying genes 4311 – 4320 of 5389 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total