Klebsiella pneumoniae strain EuSCAPE_IT256

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT256 is a gram-negative, rod-shaped bacterium that is a facultative anaerobe, capable of thriving in both aerobic and anaerobic environments. This strain is chemoheterotrophic, utilizing organic compounds for energy, and exhibits mobility due to the presence of flagella. It typically exists in various arrangements, including chains, pairs, and singles. EuSCAPE_IT256 has a mesophilic temperature range, with an optimal growth temperature of 37°C, which aligns with the body temperature of its primary host, Homo sapiens. This strain is associated with a wide array of hosts, including domestic animals such as Gallus gallus (chickens), Sus scrofa (pigs), and Canis lupus familiaris (dogs), as well as various metazoans and plants. The pathogenicity of K. pneumoniae EuSCAPE_IT256 is significant, as it is known to cause a variety of serious health conditions in humans, including bacteremia, urinary tract infections, pneumonia, and sepsis, among others. Its ability to infect multiple hosts suggests a versatile ecological role, allowing it to thrive in diverse environments, including those associated with both humans and animals. The presence of this strain in various hosts highlights its potential as an opportunistic pathogen, especially in immunocompromised individuals. Its free-living nature, coupled with its capacity to cause a range of infections, emphasizes the importance of monitoring its spread and understanding its interactions within different ecosystems.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT256

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT256
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT256 genome assembly,

Gene Summary

Adenine Count

1206076 bp

Thymine Count

1214822 bp

Guanine Count

1629429 bp

Cytosine Count

1602341 bp

Genome Length

5652668 bp

Protein-coding Genes

5086 genes

Non-Coding Genes

378 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
uracil permeaseSAMEA3538623_01064Not AvailableNegative1126605 - 112792745300.0
putative flavin:nadh reductaseSAMEA3538623_01065Not AvailableNegative1127949 - 112844317665.1
reductase ruteSAMEA3538623_01066Not AvailableNegative1128454 - 112904421539.5
hydrolase or acyltransferase rutdSAMEA3538623_01067Not AvailableNegative1129041 - 112984428411.3
ring-opening amidohydrolase rutc in pyrimidine catabolism pathwaySAMEA3538623_01068Not AvailableNegative1129841 - 113023313868.7
amidohydrolase rutb in pyrimidine catabolism pathwaySAMEA3538623_01069Not AvailableNegative1130226 - 113093625872.8
monooxygenase ruta in pyrimidine catabolism pathwaySAMEA3538623_01070Not AvailableNegative1130936 - 113202739919.4
transcriptional regulator rutrSAMEA3538623_01071Not AvailablePositive1132312 - 113295023471.6
secreted proteinSAMEA3538623_01072Not AvailableNegative1132947 - 113334214047.7
puta and putp / proline dehydrogenase transcriptional repressorSAMEA3538623_01073Not AvailableNegative1133528 - 1137166132504.0

Displaying genes 1351 – 1360 of 5464 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total