Klebsiella pneumoniae strain EuSCAPE_IT237

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT237 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, functioning as a chemoheterotroph. This strain is characterized by its ability to exist in various arrangements, including chains, pairs, and singles, and possesses flagella, which contributes to its mobility. Its optimal growth temperature is 37°C, placing it within the mesophilic range. EuSCAPE_IT237 has a complex biotic relationship, being free-living yet primarily associated with hosts, including Homo sapiens and various animal species such as Gallus gallus, Sus scrofa, and Canis lupus familiaris, among others. This wide host range underscores its adaptability and potential for zoonotic transmission. Klebsiella pneumoniae is known for its pathogenicity in humans, causing a variety of serious health conditions, including bacteremia, urinary tract infections, and pneumonia. The strain is associated with multiple infections, such as cystitis, intra-abdominal infections, and neonatal sepsis, indicating its significant role in both community and hospital-acquired infections. With a single replicon and a double membrane structure, EuSCAPE_IT237 is nonsporulating, which influences its survival strategies in host-associated environments. The strain's pathogenic potential and ability to thrive in diverse host organisms highlight its ecological adaptability and the importance of monitoring its prevalence in clinical settings. Understanding the traits of Klebsiella pneumoniae strain EuSCAPE_IT237 is vital for addressing its health impacts on both humans and animals.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT237

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT237
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT237 genome assembly,

Gene Summary

Adenine Count

1166977 bp

Thymine Count

1174846 bp

Guanine Count

1580592 bp

Cytosine Count

1544129 bp

Genome Length

5466544 bp

Protein-coding Genes

4954 genes

Non-Coding Genes

137 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
diadenosine tetraphosphataseSAMEA3538604_03986Not AvailableNegative4274257 - 427510531599.5
apag proteinSAMEA3538604_03987Not AvailableNegative4275110 - 427548713999.7
dimethyladenosine transferaseSAMEA3538604_03988Not AvailableNegative4275490 - 427631130584.2
4-hydroxythreonine-4-phosphate dehydrogenaseSAMEA3538604_03989Not AvailableNegative4276308 - 427729735079.8
survival protein sura precursor (peptidyl-prolyl cis-trans isomerase sura)SAMEA3538604_03990Not AvailableNegative4277303 - 427858947065.3
outer membrane protein impSAMEA3538604_03991Not AvailableNegative4278644 - 428099288493.1
dnaj-like protein djlaSAMEA3538604_03992Not AvailablePositive4281236 - 428206330961.5
two-component response regulator for citrateSAMEA3538604_03993Not AvailableNegative4282096 - 428279426200.5
two-component sensor kinase for citrateSAMEA3538604_03994Not AvailableNegative4282784 - 428440960789.8
malate na(+) symporterSAMEA3538604_03995Not AvailablePositive4284734 - 428609848186.9

Displaying genes 3991 – 4000 of 5091 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total