Klebsiella pneumoniae strain EuSCAPE_IT088

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT088 is a Gram-negative, rod-shaped bacterium recognized for its pathogenicity in humans. It is a facultative anaerobe, capable of utilizing a variety of organic compounds as a chemoheterotroph. This strain exhibits a mobility characteristic, facilitated by the presence of flagella, and typically arranges itself in chains, pairs, or as single cells. EuSCAPE_IT088 thrives optimally at 37°C, positioning it within a mesophilic temperature range. It possesses a complex cellular structure, characterized by two membranes and a single replicon. The bacterium is primarily host-associated, with a diverse range of hosts, including Homo sapiens, various avian species (Gallus gallus, Phasianidae), and other vertebrates like Danio rerio, Ovis aries, and Canis lupus familiaris. This strain is associated with a multitude of health effects, including serious conditions such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The extensive list of associated infections underscores its potential impact on human health, particularly in immunocompromised individuals. The ecological insight derived from this bacterium's traits indicates its significant adaptability and role in diverse environments, both within and outside of host organisms. Its ability to cause a wide range of infections emphasizes the importance of understanding Klebsiella pneumoniae in clinical settings, especially given its presence in various animal hosts and its implications for zoonotic transfer and public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT088

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT088
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT088 genome assembly,

Gene Summary

Adenine Count

1221531 bp

Thymine Count

1214443 bp

Guanine Count

1621599 bp

Cytosine Count

1628335 bp

Genome Length

5685908 bp

Protein-coding Genes

5085 genes

Non-Coding Genes

425 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
lipoate regulatory protein ybedSAMEA3515117_00922Not AvailableNegative995599 - 9958629785.79
d-alanyl-d-alanine carboxypeptidaseSAMEA3515117_00923Not AvailableNegative995975 - 99724646661.0
rare lipoprotein aSAMEA3515117_00924Not AvailableNegative997313 - 99846139102.5
rod shape-determining protein rodaSAMEA3515117_00925Not AvailableNegative998473 - 99958540462.6
penicillin-binding protein 2 (pbp-2)SAMEA3515117_00926Not AvailableNegative999585 - 100148670985.6
lsu m3psi1915 methyltransferase rlmh /ybeaSAMEA3515117_00927Not AvailableNegative1001514 - 100198117447.2
iojap proteinSAMEA3515117_00928Not AvailableNegative1001985 - 100230211569.0
alpha-ribazole-5'-phosphate phosphataseSAMEA3515117_00929Not AvailableNegative1002525 - 100315423758.3
nicotinic acid mononucleotide adenylyltransferaseSAMEA3515117_00930Not AvailableNegative1003227 - 100387724869.9
dna polymerase iii subunit deltaSAMEA3515117_00931Not AvailableNegative1003870 - 100490438746.0

Displaying genes 1221 – 1230 of 5510 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total