Klebsiella pneumoniae strain EuSCAPE_IT021

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_IT021 is a facultative anaerobic, Gram-negative bacterium characterized by its rod shape and mobility, facilitated by the presence of flagella. This strain typically forms chains, pairs, or singles and is classified as a chemoheterotroph, indicating its reliance on organic compounds for energy. Optimal growth occurs at 37°C within a mesophilic temperature range, highlighting its adaptation to human body temperature. EuSCAPE_IT021 is notably associated with a wide variety of hosts, including Homo sapiens, Gallus gallus, and various other metazoan species, underlining its ecological versatility. This strain is recognized for its pathogenicity in humans, contributing to a range of serious health conditions such as bacteremia, urinary tract infections, pneumonia, and sepsis. It is implicated in several infections, including intra-abdominal infections, liver abscesses, and neonatal sepsis, reflecting its significant role in clinical microbiology as a pathogen of concern. The bacterium is nonsporulating and possesses a single replicon and two membranes, typical of Gram-negative organisms. Its free-living nature allows it to thrive in diverse environments, potentially contributing to its transmission among various hosts. Understanding the ecological and biological characteristics of Klebsiella pneumoniae strain EuSCAPE_IT021 is essential for addressing its role in human health and disease, especially given its capacity to cause a variety of infections in different hosts. The strain's adaptability and pathogenic potential underscore the need for ongoing surveillance and research in microbial epidemiology and antibiotic resistance.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_IT021

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_IT021
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_IT021 genome assembly,

Gene Summary

Adenine Count

1149346 bp

Thymine Count

1145552 bp

Guanine Count

1540442 bp

Cytosine Count

1548426 bp

Genome Length

5383766 bp

Protein-coding Genes

4894 genes

Non-Coding Genes

295 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
dna gyrase subunit bSAMEA3538582_04128Not AvailableNegative4304441 - 430685590082.2
dna recombination and repair protein recfSAMEA3538582_04129Not AvailableNegative4306884 - 430795740575.6
dna polymerase iii subunit betaSAMEA3538582_04130Not AvailableNegative4308104 - 430920440483.9
chromosomal replication initiator protein dnaaSAMEA3538582_04131Not AvailableNegative4309209 - 431061252369.6
rnase pSAMEA3538582_04132Not AvailableNegative4311420 - 43116177282.6
membrane protein insertaseSAMEA3538582_04133Not AvailablePositive4311967 - 431361361467.5
gtpase and trna-u34 5-formylation enzyme trmeSAMEA3538582_04134Not AvailablePositive4313808 - 431517249102.7
n-acetyltransferase gcn5SAMEA3538582_04135Not AvailablePositive4315302 - 431572115198.4
transport proteinSAMEA3538582_04136Not AvailablePositive4315821 - 431699941732.5
lysr-family transcriptional regulator yidzSAMEA3538582_04137Not AvailablePositive4316974 - 431793337026.0

Displaying genes 4181 – 4190 of 5189 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total