Klebsiella pneumoniae strain EuSCAPE_DE082

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_DE082 is a gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, classifying it as a chemoheterotroph. It is capable of mobility due to the presence of flagella, and it typically arranges itself in chains, pairs, or as singles. The strain is mesophilic, with an optimal growth temperature of 37°C, which is consistent with its natural habitat as a host-associated organism. This strain has significant pathogenic potential in humans, being associated with a wide range of health effects, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Other noted health impacts include liver abscesses, meningitis, and bloodstream infections, indicating its role in severe clinical conditions such as sepsis and neonatal sepsis. The bacterium is also implicated in infections across a diverse range of hosts, including Homo sapiens, various avian species, and several mammals, highlighting its ecological versatility. With a single replicon and a double membrane structure, Klebsiella pneumoniae EuSCAPE_DE082's nonsporulating nature suggests a reliance on host environments for survival and propagation. Its ability to thrive in multiple hosts, coupled with its pathogenicity in humans, underscores its importance in both clinical microbiology and public health. This strain exemplifies the interconnectedness of microbial life and host organisms, illustrating how certain bacteria can adapt and thrive across different biological systems while posing significant health risks.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_DE082

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_DE082
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_DE082 genome assembly,

Gene Summary

Adenine Count

1165428 bp

Thymine Count

1163771 bp

Guanine Count

1567273 bp

Cytosine Count

1551621 bp

Genome Length

5448093 bp

Protein-coding Genes

4924 genes

Non-Coding Genes

236 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
peptidyl-prolyl cis-trans isomerase suraSAMEA3512110_02705Not AvailableNegative2892594 - 289388047065.3
organic solvent tolerance proteinSAMEA3512110_02706Not AvailableNegative2893935 - 289625087253.5
dnaj-like protein djlaSAMEA3512110_02707Not AvailablePositive2896527 - 289735430961.5
transcriptional regulatory protein citbSAMEA3512110_02708Not AvailableNegative2897387 - 289808526142.4
sensor histidine kinase citaSAMEA3512110_02709Not AvailableNegative2898075 - 289970060789.8
citrate/malate-proton symporterSAMEA3512110_02710Not AvailablePositive2900031 - 290139548154.8
2'-(5''-triphosphoribosyl)-3'-dephospho-coa:apo- citrate lyaseSAMEA3512110_02711Not AvailablePositive2901575 - 290211420091.2
ribosomal large subunit pseudouridine synthase aSAMEA3512110_02712Not AvailableNegative2902189 - 290284825015.3
rna polymerase-associated protein rapaSAMEA3512110_02713Not AvailableNegative2902861 - 2905767109609.0
dna polymerase iiSAMEA3512110_02714Not AvailableNegative2905955 - 290831289893.7

Displaying genes 2821 – 2830 of 5160 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total