Klebsiella pneumoniae strain EuSCAPE_DE076

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_DE076 is a Gram-negative, rod-shaped bacterium that exhibits a chemoheterotrophic metabolism. It is classified as a facultative anaerobe, allowing it to thrive in both aerobic and anaerobic environments. This strain typically forms chains, pairs, or occurs as single cells, and is motile due to the presence of flagella. Its optimal growth temperature is 37°C, placing it within the mesophilic range. K. pneumoniae EuSCAPE_DE076 is associated with a variety of hosts, including Homo sapiens, Gallus gallus, and several other metazoans and vertebrates. This broad host range indicates its ecological versatility and adaptability in diverse environments. Clinically, this strain is known for its pathogenicity in humans, causing a multitude of health issues such as bacteremia, urinary tract infections, pneumonia, and meningitis, among others. These infections can lead to severe health consequences, including sepsis and intra-abdominal infections. The strain is characterized by its nonsporulating nature and has a single replicon with a double membrane structure. Its free-living biotic relationship suggests that, while it can cause disease, it also exists in a non-pathogenic state in the environment. The ecological implications of K. pneumoniae EuSCAPE_DE076’s ability to infect a wide range of hosts highlight its potential role in the transmission of antibiotic resistance and the need for ongoing surveillance in both clinical and environmental contexts. This underscores the importance of understanding its biology for better management and treatment of infections it may cause.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_DE076

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_DE076
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_DE076 genome assembly,

Gene Summary

Adenine Count

1170205 bp

Thymine Count

1175138 bp

Guanine Count

1566868 bp

Cytosine Count

1586532 bp

Genome Length

5498743 bp

Protein-coding Genes

4945 genes

Non-Coding Genes

280 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
putative enzymeSAMEA3512104_03686Not AvailablePositive3895869 - 389744959550.1
outer membrane protein xSAMEA3512104_03687Not AvailableNegative3897540 - 389805218464.4
dmt superfamily metabolite efflux proteinSAMEA3512104_03688Not AvailablePositive3898404 - 389929131211.4
non-specific dna-binding protein dps / iron-binding ferritin-like antioxidant protein / ferroxidaseSAMEA3512104_03689Not AvailablePositive3899529 - 390003218709.3
glutamine abc transporter periplasmic proteinSAMEA3512104_03690Not AvailablePositive3900441 - 390118727153.5
glutamate transport membrane-spanning proteinSAMEA3512104_03691Not AvailablePositive3901313 - 390197224264.8
glutamate transport atp-binding proteinSAMEA3512104_03692Not AvailablePositive3901969 - 390269126678.6
potassium efflux system kefa protein / small-conductance mechanosensitive channelSAMEA3512104_03693Not AvailablePositive3902803 - 390499880099.1
ribosomal rna large subunit methyltransferase fSAMEA3512104_03694Not AvailableNegative3905001 - 390591533954.5
nitrilotriacetate monooxygenase component bSAMEA3512104_03695Not AvailablePositive3906012 - 390662622515.6

Displaying genes 3751 – 3760 of 5225 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total