Klebsiella pneumoniae strain EuSCAPE_DE005

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_DE005 is a Gram-negative, rod-shaped bacterium that exhibits a variety of pathogenic effects, particularly in humans. This strain is a facultative anaerobe, enabling it to thrive in both aerobic and anaerobic environments. It is characterized by its mobility, attributed to the presence of flagella, and typically forms chains, pairs, or single cells. As a chemoheterotroph, Klebsiella pneumoniae utilizes organic compounds as an energy source, which aligns with its habitat primarily being host-associated. This strain has a broad range of potential hosts, including Homo sapiens, Gallus gallus, and various other metazoans and plants, indicating its versatility in colonizing different environments. Klebsiella pneumoniae EuSCAPE_DE005 is associated with several severe health issues, including bacteremia, urinary tract infections, pneumonia, and meningitis, among others. These infections can lead to critical conditions such as sepsis and neonatal sepsis, highlighting its significance in clinical microbiology. The strain is mesophilic, with an optimal growth temperature of 37°C, which corresponds with the human body temperature, further facilitating its role as a human pathogen. The nonsporulating nature of this bacterium suggests a reliance on direct transmission or environmental persistence rather than resilience through a dormant state. In summary, Klebsiella pneumoniae strain EuSCAPE_DE005 exemplifies the complex interactions between pathogenic bacteria and their hosts. Its diverse pathogenic capabilities and adaptability to various biological hosts illustrate the challenges in managing infections it causes, emphasizing the need for ongoing surveillance and research in clinical settings.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_DE005

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_DE005
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_DE005 genome assembly,

Gene Summary

Adenine Count

1185763 bp

Thymine Count

1180867 bp

Guanine Count

1569573 bp

Cytosine Count

1584413 bp

Genome Length

5520616 bp

Protein-coding Genes

5073 genes

Non-Coding Genes

146 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
type vi secretion system effectorSAMEA3512032_03464Not AvailableNegative3705197 - 370568218175.7
uncharacterised proteinSAMEA3512032_03465Not AvailablePositive3706717 - 370743027455.8
uncharacterised proteinSAMEA3512032_03466Not AvailableNegative3708051 - 370851217812.6
Hypothetical proteinSAMEA3512032_03467Not AvailableNegative3708578 - 370907819628.3
uncharacterised proteinSAMEA3512032_03468Not AvailableNegative3709152 - 37093045505.8
uncharacterised proteinSAMEA3512032_03469Not AvailableNegative3709656 - 371003314551.3
IntegraseSAMEA3512032_03470Not AvailableNegative3710558 - 371249274627.9
Serine kinaseSAMEA3512032_03471Not AvailablePositive3712571 - 371450574394.3
Conserved bacterial proteinSAMEA3512032_03472Not AvailablePositive3714591 - 371587449350.1
lipoproteinSAMEA3512032_03473Not AvailableNegative3715920 - 371648320679.9

Displaying genes 21 – 30 of 5219 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total