Klebsiella pneumoniae strain EuSCAPE_LT004

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_LT004 is a Gram-negative, facultative anaerobic bacterium belonging to the family Enterobacteriaceae. Its morphology is characterized by rod-shaped cells that can be arranged in chains, pairs, or singles. This strain is motile and possesses flagella, which contributes to its ability to move in various environments. As a chemoheterotroph, it derives energy from organic compounds, adapting to a range of ecological niches, primarily associated with hosts, including humans and various animal species such as chickens, pigs, and dogs. K. pneumoniae strain EuSCAPE_LT004 is mesophilic, with an optimal growth temperature of 37°C, which corresponds to the body temperature of its primary human host, Homo sapiens. Its pathogenicity is significant, as it is associated with a variety of serious health conditions, including bacteremia, pneumonia, urinary tract infections, and sepsis, among others. The strain is nonsporulating and has a single chromosomal replicon, with a typical double membrane structure characteristic of Gram-negative bacteria. The diverse range of hosts and the extensive list of associated health effects highlight the ecological versatility of K. pneumoniae strain EuSCAPE_LT004. Its ability to thrive in various environments while causing significant human diseases underscores its importance in clinical microbiology and public health. The strain exemplifies the complex interactions between pathogenic bacteria and their hosts, emphasizing the need for continuous surveillance and research to mitigate the threats posed by such opportunistic pathogens.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_LT004

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_LT004
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_LT004 genome assembly,

Gene Summary

Adenine Count

1163597 bp

Thymine Count

1163290 bp

Guanine Count

1557525 bp

Cytosine Count

1569539 bp

Genome Length

5453951 bp

Protein-coding Genes

4915 genes

Non-Coding Genes

245 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
betaine aldehyde dehydrogenaseSAMEA3538451_03692Not AvailablePositive3921061 - 392253052440.1
acetolactate synthase isozyme 1 large subunitSAMEA3538451_03693Not AvailablePositive3922544 - 392418457947.7
porin d precursorSAMEA3538451_03694Not AvailableNegative3924321 - 392558946647.8
uncharacterized metalloprotease ygggSAMEA3538451_03695Not AvailableNegative3925967 - 392672526848.8
n,n'-diacetylchitobiose-specific phosphotransferase enzyme iia componentSAMEA3538451_03696Not AvailableNegative3927622 - 392792411331.6
pts system oligo-beta-mannoside-specific eiic componentSAMEA3538451_03697Not AvailableNegative3928022 - 392934448198.3
oligo-beta-mannoside-specific phosphotransferase enzyme iib componentSAMEA3538451_03698Not AvailableNegative3929356 - 392967011577.2
cryptic asc operon repressorSAMEA3538451_03699Not AvailablePositive3929961 - 393090534261.1
4-hydroxybenzoate transporter pcakSAMEA3538451_03700Not AvailablePositive3931117 - 393248748806.1
protocatechuate 4,5-dioxygenase beta chainSAMEA3538451_03701Not AvailablePositive3932501 - 393376347134.3

Displaying genes 3801 – 3810 of 5160 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total