Klebsiella pneumoniae strain EuSCAPE_AT001

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_AT001 is a gram-negative, facultative anaerobic bacterium characterized by its rod shape and the ability to form chains, pairs, or exist as single cells. This strain is known to be a chemoheterotroph, deriving energy from organic compounds. It is mesophilic, with an optimal growth temperature of 37°C, which aligns with the human body temperature, making it well-suited for infections in warm-blooded hosts. The strain possesses flagella, indicating mobility, and has a complex cellular structure, featuring two membranes and a single replicon. Its biotic relationship is categorized as free-living, allowing it to thrive in various environments, particularly within host-associated habitats. K. pneumoniae strain EuSCAPE_AT001 has a significant impact on human health, being associated with a wide range of infections, including bacteremia, urinary tract infections, pneumonia, and meningitis, among others. The strain's pathogenicity is predominantly human-centric, but it can also infect a variety of other hosts, such as Gallus gallus (chickens), Canis lupus familiaris (domestic dogs), and Danio rerio (zebrafish), indicating its versatility as a pathogen. The extensive range of infections caused by this strain underscores its role in both clinical settings and ecological niches, revealing the challenges posed by Klebsiella pneumoniae in healthcare. Understanding its traits and host interactions can inform strategies for managing infections and highlight the importance of monitoring antibiotic resistance mechanisms within this species.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_AT001

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_AT001
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_AT001 genome assembly,

Gene Summary

Adenine Count

1219614 bp

Thymine Count

1225151 bp

Guanine Count

1642784 bp

Cytosine Count

1600027 bp

Genome Length

5687576 bp

Protein-coding Genes

5057 genes

Non-Coding Genes

394 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
catechol 1,2-dioxygenaseSAMEA3499873_01626Not AvailableNegative1705439 - 170636534290.3
muconolactone isomeraseSAMEA3499873_01627Not AvailableNegative1706432 - 170672211212.6
l-ala-d/l-glu epimeraseSAMEA3499873_01628Not AvailableNegative1706742 - 170786039011.1
pca regulon regulatory protein pcarSAMEA3499873_01629Not AvailablePositive1708114 - 170891128290.6
methyl viologen resistance protein smvaSAMEA3499873_01630Not AvailableNegative1708906 - 171040551651.3
transcriptional regulator tetr familySAMEA3499873_01631Not AvailablePositive1710568 - 171110419945.2
nitrate/nitrite transport protein naruSAMEA3499873_01632Not AvailablePositive1711279 - 171266149498.4
respiratory nitrate reductase subunit alphaSAMEA3499873_01633Not AvailablePositive1712776 - 1716516139848.0
respiratory nitrate reductase subunit betaSAMEA3499873_01634Not AvailablePositive1716513 - 171805758432.7
respiratory nitrate reductase subunit deltaSAMEA3499873_01635Not AvailablePositive1718057 - 171875226071.2

Displaying genes 1861 – 1870 of 5451 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total