Klebsiella pneumoniae strain EuSCAPE_SK001

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_SK001 is a Gram-negative, rod-shaped bacterium that displays a range of pathogenic capabilities, primarily affecting humans but also associated with various other hosts including birds, fish, and mammals. This strain is a facultative anaerobe, allowing it to thrive in both aerobic and anaerobic environments, and it is classified as a chemoheterotroph, utilizing organic compounds for energy. Under optimal conditions, specifically at 37°C, EuSCAPE_SK001 exhibits mobility due to the presence of flagella, allowing for movement in its environment. Its cellular arrangement can be observed in varying forms including chains, pairs, and singles, indicating a degree of flexibility in its growth patterns. This bacterium is free-living in its ecological niche but is known to cause a wide array of health issues in humans, including but not limited to bacteremia, urinary tract infections, pneumonia, and sepsis. The strain has been implicated in both community-acquired and healthcare-associated infections, reflecting its significant role as a human pathogen. The versatility of K. pneumoniae strain EuSCAPE_SK001, including its ability to infect multiple hosts and cause serious health complications, underscores the importance of monitoring and understanding its behavior in clinical and environmental contexts. Its presence in diverse habitats and among various hosts highlights the potential for zoonotic transmission and the need for comprehensive approaches to manage infections it may cause.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_SK001

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_SK001
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_SK001 genome assembly,

Gene Summary

Adenine Count

1184876 bp

Thymine Count

1182076 bp

Guanine Count

1574168 bp

Cytosine Count

1599215 bp

Genome Length

5540335 bp

Protein-coding Genes

5014 genes

Non-Coding Genes

311 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
general secretion pathway protein mSAMEA3500069_03749Not AvailablePositive3970230 - 397071518257.2
general secretion pathway protein nSAMEA3500069_03750Not AvailablePositive3970705 - 397145127143.1
leader peptidase (prepilin peptidase)SAMEA3500069_03751Not AvailablePositive3971448 - 397224829420.7
atp-dependent helicase hrpbSAMEA3500069_03752Not AvailableNegative3972296 - 397472588727.9
2'-5' rna ligaseSAMEA3500069_03753Not AvailablePositive3974798 - 397533420258.3
sugar/maltose fermentation stimulation proteinSAMEA3500069_03754Not AvailablePositive3975334 - 397605026391.6
rna polymerase-binding transcription factorSAMEA3500069_03755Not AvailablePositive3976213 - 397666817486.7
glutamyl-q-trna synthetaseSAMEA3500069_03756Not AvailablePositive3976728 - 397760932962.0
poly(a) polymeraseSAMEA3500069_03757Not AvailablePositive3977705 - 397906652403.3
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinaseSAMEA3500069_03758Not AvailablePositive3979063 - 397954217691.3

Displaying genes 3931 – 3940 of 5325 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total