Klebsiella pneumoniae strain EuSCAPE_FR020

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_FR020 is a Gram-negative, rod-shaped bacterium that exhibits a diverse range of pathogenic effects on multiple hosts, particularly Homo sapiens. As a facultative anaerobe, it can thrive in both aerobic and anaerobic environments, and it is classified as a chemoheterotroph, relying on organic compounds for energy. The strain is capable of mobility due to the presence of flagella and typically forms chains, pairs, or singles. This strain has a mesophilic optimal growth temperature of 37°C, which aligns with the human body temperature, facilitating its role as a significant pathogen. Klebsiella pneumoniae is associated with numerous health complications, including bacteremia, urinary tract infections, pneumonia, and a variety of intra-abdominal infections. These infections can lead to severe conditions such as sepsis and neonatal sepsis, emphasizing the strain's clinical importance. The ecological versatility of Klebsiella pneumoniae EuSCAPE_FR020 is notable, as it has a free-living biotic relationship and can infect a wide range of hosts, including Gallus gallus, Danio rerio, and Sus scrofa, among others. This broad host range may contribute to its persistence in various environments and its potential to adapt to different ecological niches. The presence of a single replicon and two membranes is consistent with its classification as a member of the Enterobacteriaceae family. Understanding the traits of this strain can aid in developing targeted strategies for managing infections it causes, particularly in healthcare settings.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_FR020

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_FR020
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_FR020 genome assembly,

Gene Summary

Adenine Count

1156993 bp

Thymine Count

1154224 bp

Guanine Count

1545899 bp

Cytosine Count

1552310 bp

Genome Length

5409426 bp

Protein-coding Genes

4987 genes

Non-Coding Genes

137 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
alkanesulfonates abc transporter atp-binding protein / sulfonate abc transporterSAMEA3500005_00160Not AvailablePositive172572 - 17334528130.4
tonb-dependent siderophore receptorSAMEA3500005_00161Not AvailableNegative173928 - 17600075557.5
transportSAMEA3500005_00162Not AvailablePositive176506 - 17732729939.4
iron compound permease protein of abc transporter familySAMEA3500005_00163Not AvailablePositive177324 - 17834934756.2
permease of ferrichrome abc transporterSAMEA3500005_00164Not AvailablePositive178346 - 17939836762.8
putative iron compound abc transport system periplasmic binding componentSAMEA3500005_00165Not AvailablePositive179412 - 18036534912.9
putative transcriptional regulatorSAMEA3500005_00166Not AvailablePositive180362 - 18126432681.8
amino acid abc transporter periplasmic amino acid-binding proteinSAMEA3500005_00167Not AvailablePositive181357 - 18212427701.2
amino acid abc transporterSAMEA3500005_00168Not AvailablePositive182188 - 18295228326.1
histidine abc transporter atp-binding proteinSAMEA3500005_00169Not AvailablePositive182939 - 18366126332.2

Displaying genes 221 – 230 of 5124 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total