Klebsiella pneumoniae strain EuSCAPE_AT006

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_AT006 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, relying on chemoheterotrophic energy sources. It is capable of existing in various cell arrangements, including chains, pairs, and singles, and demonstrates mobility due to the presence of flagella. The strain thrives optimally at a temperature of 37°C, fitting within the mesophilic temperature range, which is common for many human-associated pathogens. This bacterium is primarily host-associated and has a wide array of potential hosts, including humans (Homo sapiens), various mammals (e.g., Canis lupus familiaris, Sus scrofa, Equidae), birds (Aves, Phasianidae), and several other taxa such as fish (Danio rerio) and plants (Viridiplantae). Its free-living relationship in the environment highlights its adaptability and potential for transmission across different hosts. Klebsiella pneumoniae strain EuSCAPE_AT006 is known for its pathogenicity in humans, associated with a range of serious health effects. These include bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. The strain is implicated in severe conditions such as sepsis and neonatal sepsis, highlighting its clinical significance in healthcare settings. The diversity in hosts and the strain's pathogenic capabilities suggest that Klebsiella pneumoniae plays a complex role in both human health and the broader ecological landscape, particularly as it relates to zoonotic infections and the dynamics of microbial populations in various environments. Understanding its biology and ecological interactions is crucial for developing strategies to manage its impact on health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_AT006

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_AT006
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_AT006 genome assembly,

Gene Summary

Adenine Count

1189039 bp

Thymine Count

1194180 bp

Guanine Count

1599855 bp

Cytosine Count

1587385 bp

Genome Length

5570459 bp

Protein-coding Genes

5096 genes

Non-Coding Genes

254 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
AttlNot AvailableNot AvailablePositive327677 - 327695Not Available
Tyrosine-type recombinase/integraseSAMEA3499878_00311Not AvailableNegative327770 - 32882239943.7
uncharacterised proteinSAMEA3499878_00312Not AvailableNegative328914 - 32946520559.8
Recf/recn/smc n-terminal domain proteinSAMEA3499878_00313Not AvailableNegative329462 - 33066145552.0
Repressor protein ciSAMEA3499878_00314Not AvailableNegative330670 - 33156333225.9
RegulatorSAMEA3499878_00315Not AvailablePositive331689 - 3319108153.06
Regulatory cii family proteinSAMEA3499878_00316Not AvailablePositive331943 - 33245218132.0
Hypothetical proteinSAMEA3499878_00317Not AvailablePositive332460 - 3326607717.47
Hypothetical proteinSAMEA3499878_00318Not AvailablePositive332624 - 33296512832.6
Hypothetical proteinSAMEA3499878_00319Not AvailablePositive333033 - 3332668536.14

Displaying genes 1 – 10 of 5350 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
MeningitisCausesPMC13168211
Neonatal sepsisCausesPMC13168211
PneumoniaCausesPMC13253921
Urinary tract infectionsCausesPMC13253921
BacteremiaCausesPMC13253921
Neonatal sepsisCausesPMC13253921
Pyogenic liver abscessCausesPMC13253921
MeningitisCausesPMC13253921
Early onset neonatal sepsisCausesPMC4560869
Pyogenic liver abscessCausesPMC7332619

Displaying health effects 21 – 30 of 53 in total