Klebsiella pneumoniae strain EuSCAPE_TR001

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_TR001 is a Gram-negative, rod-shaped bacterium that exhibits mobility due to the presence of flagella. This strain is classified as a facultative anaerobe, allowing it to thrive in both aerobic and anaerobic environments. It is a chemoheterotroph, deriving energy from organic compounds, and typically grows optimally at 37°C, falling within the mesophilic temperature range. The bacterium is found in host-associated habitats and has a diverse range of potential hosts, including Homo sapiens (humans), various species of birds (Gallus gallus, Phasianidae, Aves), and mammals (Canis lupus familiaris, Sus scrofa, Equidae, and others). This adaptability to multiple hosts underscores its ecological versatility and potential for transmission across species. Klebsiella pneumoniae strain EuSCAPE_TR001 is associated with various health effects, primarily in humans, where it can lead to serious infections such as bacteremia, pneumonia, urinary tract infections, and sepsis. Its pathogenicity is significant, particularly in immunocompromised individuals, as it can cause a range of complications from intra-abdominal infections to neonatal sepsis. The bacterium’s nonsporulating nature and its biotic relationship as a free-living organism highlight its role in both environmental and clinical settings. Understanding the ecological dynamics and pathogenic potential of Klebsiella pneumoniae strain EuSCAPE_TR001 is crucial for addressing its impact on human health and developing effective treatment strategies.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_TR001

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_TR001
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_TR001 genome assembly,

Gene Summary

Adenine Count

1243014 bp

Thymine Count

1248405 bp

Guanine Count

1646291 bp

Cytosine Count

1625905 bp

Genome Length

5763615 bp

Protein-coding Genes

5087 genes

Non-Coding Genes

459 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
acetolactate synthase catalytic subunitSAMEA3727722_02308Not AvailableNegative2435000 - 243670961344.3
transporterSAMEA3727722_02309Not AvailableNegative2436745 - 243768633448.8
transcriptional regulatory proteinSAMEA3727722_02310Not AvailablePositive2437871 - 243875833114.7
nitrous oxide-stimulated promoterSAMEA3727722_02311Not AvailablePositive2438826 - 243916713540.7
manganese abc transporter, inner membrane permease protein sitdSAMEA3727722_02312Not AvailableNegative2439234 - 244008829779.8
manganese abc transporterSAMEA3727722_02313Not AvailableNegative2440082 - 244093030319.1
manganese abc transporter, atp-binding protein sitbSAMEA3727722_02314Not AvailableNegative2440927 - 244174829823.9
manganese abc transporter substrate-binding protein sitaSAMEA3727722_02315Not AvailableNegative2441745 - 244266233609.2
sugar binding transcriptional regulator laci familySAMEA3727722_02316Not AvailableNegative2442841 - 244380335063.9
rok family glucokinase with ambiguous substrate specificitySAMEA3727722_02317Not AvailableNegative2443860 - 244477432356.9

Displaying genes 2641 – 2650 of 5546 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total