Klebsiella pneumoniae strain EuSCAPE_TR125

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_TR125 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, utilizing chemoheterotrophic energy sources. This strain is known for its mobility due to the presence of flagella and typically forms chains, pairs, or exists as single cells. It thrives optimally at 37°C, falling within a mesophilic temperature range. K. pneumoniae strain EuSCAPE_TR125 is associated with a variety of hosts, including Homo sapiens, Gallus gallus, and several other animal and plant species. Its pathogenesis is significant, as it is linked to numerous health issues in humans, including bacteremia, urinary tract infections, pneumonia, and other severe conditions such as meningitis and sepsis. The strain is nonsporulating and has a single replicon with a double membrane structure. The ecological insight derived from the traits of K. pneumoniae strain EuSCAPE_TR125 suggests that its adaptability to diverse hosts, including mammals, birds, and even plants, underlines its potential for opportunistic infections. The capacity to inhabit various ecological niches may facilitate its transmission and survival in different environments, ultimately contributing to its clinical relevance and the challenges it poses in healthcare settings. Understanding its pathogenicity and biotic relationships is essential for developing strategies to manage infections caused by this strain.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_TR125

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_TR125
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_TR125 genome assembly,

Gene Summary

Adenine Count

1171542 bp

Thymine Count

1172209 bp

Guanine Count

1564576 bp

Cytosine Count

1574966 bp

Genome Length

5483293 bp

Protein-coding Genes

4983 genes

Non-Coding Genes

189 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
bifunctional aldehyde dehydrogenase/enoyl-coa hydrataseSAMEA3729652_03463Not AvailableNegative3687585 - 368963072995.7
phenylacetate-coa oxygenaseSAMEA3729652_03464Not AvailablePositive3689917 - 369084635251.8
phenylacetate-coa oxygenaseSAMEA3729652_03465Not AvailablePositive3690858 - 369114510934.8
phenylacetate-coa oxygenase, paai subunitSAMEA3729652_03466Not AvailablePositive3691153 - 369190827957.1
phenylacetic acid degradation proteinSAMEA3729652_03467Not AvailablePositive3691920 - 369241718245.8
phenylacetate-coa oxygenase/reductase, paak subunitSAMEA3729652_03468Not AvailablePositive3692425 - 369349538993.6
phenylacetate degradation enoyl-coa hydratase paaaSAMEA3729652_03469Not AvailablePositive3693492 - 369425927412.1
enoyl-coa hydrataseSAMEA3729652_03470Not AvailablePositive3694262 - 369505028077.8
3-hydroxyacyl-coa dehydrogenaseSAMEA3729652_03471Not AvailablePositive3695054 - 369647550839.3
phenylacetic acid degradation protein paad, thioesteraseSAMEA3729652_03472Not AvailablePositive3696465 - 369688715177.2

Displaying genes 3471 – 3480 of 5172 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total