Klebsiella pneumoniae strain EuSCAPE_BE083

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_BE083 is a significant pathogenic bacterium primarily associated with human health. It is a gram-negative, rod-shaped organism that exhibits a facultative anaerobic metabolism, relying on chemoheterotrophic energy sources. This strain can be found in diverse habitats, predominantly in association with various hosts, including Homo sapiens, Gallus gallus, and multiple other metazoans and plants. The strain typically exists in chains, pairs, or as single cells, and possesses flagella, indicating its mobility. With an optimal growth temperature of 37°C, it is classified as mesophilic, thriving in moderate temperature ranges. This strain has a unique cellular architecture, characterized by two membranes and a single replicon. Klebsiella pneumoniae strain EuSCAPE_BE083 is known for its pathogenic potential, being associated with a variety of severe health issues in humans, including bacteremia, urinary tract infections, pneumonia, and several intra-abdominal infections. The strain's ability to cause a wide range of infections, such as septicemia and neonatal sepsis, underscores its clinical relevance and the challenges it poses in healthcare settings. The ecological role of K. pneumoniae strain EuSCAPE_BE083 extends beyond human pathogens; it is free-living and interacts with various hosts, highlighting its adaptability and potential impact on both human health and environmental microbiomes. This adaptability may contribute to its survival and spread in diverse ecological niches, emphasizing the importance of monitoring such strains in clinical and environmental contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_BE083

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_BE083
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_BE083 genome assembly,

Gene Summary

Adenine Count

1215752 bp

Thymine Count

1209288 bp

Guanine Count

1600191 bp

Cytosine Count

1597776 bp

Genome Length

5623007 bp

Protein-coding Genes

5016 genes

Non-Coding Genes

392 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
iron-hydroxamate transporter substrate-binding subunitSAMEA3727670_02146Not AvailablePositive2234872 - 223576232958.3
ferric hydroxamate abc transporterSAMEA3727670_02147Not AvailablePositive2235759 - 223774170223.0
glutamate-1-semialdehyde aminotransferaseSAMEA3727670_02148Not AvailableNegative2237878 - 223915845330.6
h(+)/cl(-) exchange transporter clcaSAMEA3727670_02149Not AvailablePositive2239297 - 224075751969.1
erpaSAMEA3727670_02150Not AvailablePositive2240839 - 224118312151.2
inner membrane proteinSAMEA3727670_02151Not AvailableNegative2241255 - 224187821947.9
vitamin b12 abc transporter, b12-binding component btufSAMEA3727670_02152Not AvailableNegative2241915 - 224271529145.2
5'-methylthioadenosine nucleosidaseSAMEA3727670_02153Not AvailableNegative2242708 - 224340624491.6
deoxyguanosinetriphosphate triphosphohydrolaseSAMEA3727670_02154Not AvailablePositive2243490 - 224500459035.8
htra protease/chaperone proteinSAMEA3727670_02155Not AvailablePositive2245139 - 224657249518.5

Displaying genes 2431 – 2440 of 5408 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total