Klebsiella pneumoniae strain EuSCAPE_BE049

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_BE049 is a gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, functioning as a chemoheterotroph. This strain is known for its mobility, facilitated by the presence of flagella, and typically forms arrangements in chains, pairs, or singles. It thrives optimally at 37°C, placing it within the mesophilic temperature range. EuSCAPE_BE049 is primarily associated with various hosts, including Homo sapiens (humans), domesticated animals such as Gallus gallus (chickens) and Sus scrofa (pigs), as well as several other vertebrates and invertebrates. The strain is notable for its significant health impacts on humans, being linked to a range of serious infections including bacteremia, pneumonia, urinary tract infections, sepsis, and liver abscesses, among others. This bacterium has a biotic relationship characterized as free-living, with a single replicon and two membranes. The variety of hosts and the pathogenicity of K. pneumoniae strain EuSCAPE_BE049 highlight its ecological versatility and potential as a significant opportunistic pathogen in both human and animal health contexts. Given its capacity to cause multiple types of infections, understanding its transmission dynamics and environmental reservoirs may inform better strategies for managing its impact on public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_BE049

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_BE049
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_BE049 genome assembly,

Gene Summary

Adenine Count

1202949 bp

Thymine Count

1204855 bp

Guanine Count

1602084 bp

Cytosine Count

1605938 bp

Genome Length

5615826 bp

Protein-coding Genes

5014 genes

Non-Coding Genes

338 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
chaperone protein hscbSAMEA3727639_03450Not AvailableNegative3635059 - 363557419825.4
iron binding protein isca for iron-sulfur cluster assemblySAMEA3727639_03451Not AvailableNegative3635649 - 363597211449.5
iron-sulfur cluster assembly scaffold protein iscuSAMEA3727639_03452Not AvailableNegative3635990 - 363637613807.3
cysteine desulfuraseSAMEA3727639_03453Not AvailableNegative3636403 - 363761745059.1
iron-sulfur cluster regulator iscrSAMEA3727639_03454Not AvailableNegative3637796 - 363828717551.9
trna:cm32/um32 methyltransferaseSAMEA3727639_03455Not AvailableNegative3638522 - 363925626799.4
inositol-1-monophosphataseSAMEA3727639_03456Not AvailablePositive3639377 - 364018029322.0
uncharacterised proteinSAMEA3727639_03457Not AvailableNegative3640294 - 364100426004.3
transporter ni2+-co2+ transporter (nicot) familySAMEA3727639_03458Not AvailableNegative3641104 - 364208435031.1
membrane proteinSAMEA3727639_03459Not AvailableNegative3642075 - 364271323549.0

Displaying genes 3651 – 3660 of 5352 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total