Klebsiella pneumoniae strain EuSCAPE_RO114

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_RO114 is a Gram-negative, rod-shaped bacterium that is classified as a facultative anaerobe and a chemoheterotroph. It is capable of existing in various arrangements, including chains, pairs, and singles, and possesses flagella, indicating motility. This strain is mesophilic, with an optimal growth temperature of 37°C, and has a single replicon surrounded by two membranes. EuSCAPE_RO114 is primarily associated with hosts such as Homo sapiens, Gallus gallus, and various other Metazoa, including domestic animals like Canis lupus familiaris and Sus scrofa, as well as aquatic species like Danio rerio. The bacterium exhibits a free-living biotic relationship, which allows it to thrive in diverse environments. The strain is known for its significant pathogenicity in humans, causing a range of serious health effects including bacteremia, urinary tract infections, pneumonia, and intra-abdominal infections, among others. It is implicated in severe conditions such as neonatal sepsis and septicemia, highlighting its potential as a critical pathogen in clinical settings. The ecological insight provided by the presence of Klebsiella pneumoniae strain EuSCAPE_RO114 across numerous hosts suggests that it may play a role in the microbial ecosystems of both human and animal populations. The bacterium's adaptability to various environments and its pathogenic potential underline the importance of understanding its distribution and mechanisms of infection, particularly in the context of antibiotic resistance and public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_RO114

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_RO114
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_RO114 genome assembly,

Gene Summary

Adenine Count

1108299 bp

Thymine Count

1109058 bp

Guanine Count

1510462 bp

Cytosine Count

1485698 bp

Genome Length

5213517 bp

Protein-coding Genes

4745 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
3-dehydroquinate dehydrataseSAMEA3721042_03523Not AvailablePositive3784485 - 378493716429.7
acetyl-coa carboxylase biotin carboxyl carrier proteinSAMEA3721042_03524Not AvailablePositive3784960 - 378542716467.9
biotin carboxylaseSAMEA3721042_03525Not AvailablePositive3785438 - 378678749273.6
membrane proteinSAMEA3721042_03526Not AvailablePositive3786898 - 37871409193.52
sodium/panthothenate symporterSAMEA3721042_03527Not AvailablePositive3787130 - 378858151743.3
50s ribosomal protein l11 methyltransferaseSAMEA3721042_03528Not AvailablePositive3788593 - 378947431873.9
trna dihydrouridine synthase bSAMEA3721042_03529Not AvailablePositive3789832 - 379079735837.2
dna-binding protein fisSAMEA3721042_03530Not AvailablePositive3790822 - 379111811240.6
multidrug efflux pump acrab operon transcription repressorSAMEA3721042_03531Not AvailableNegative3791206 - 379185624610.9
rnd efflux system, membrane fusion protein cmeaSAMEA3721042_03532Not AvailablePositive3792235 - 379337440508.1

Displaying genes 3591 – 3600 of 4885 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total