Klebsiella pneumoniae strain EuSCAPE_HR068

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR068 is a gram-negative, rod-shaped bacterium characterized as a facultative anaerobe and a chemoheterotroph. This strain exhibits mobility due to the presence of flagella and typically arranges itself in chains, pairs, or as singles. It thrives optimally at a temperature of 37°C, indicating its mesophilic nature. This strain is notable for its significant pathogenic potential in humans, being associated with a wide range of health issues. Infections caused by K. pneumoniae can lead to bacteremia, urinary tract infections (UTIs), pneumonia, cystitis, intra-abdominal infections, liver abscesses, meningitis, and various other conditions such as septicemia and neonatal sepsis. The diverse array of diseases linked to this bacterium underscores its role as a serious human pathogen. K. pneumoniae strain EuSCAPE_HR068 is also free-living but has a broad host range, including Homo sapiens, various metazoans, and several species of animals such as Gallus gallus (chickens), Canis lupus familiaris (dogs), and Sus scrofa (pigs). This adaptability to multiple hosts suggests a complex ecological relationship within different environments, enhancing its survival and transmission potential. Understanding the pathogenicity and host associations of K. pneumoniae strain EuSCAPE_HR068 is crucial for public health, as it poses significant risks in both clinical and community settings. Addressing infections caused by this strain requires a thorough understanding of its behavior and the environments it inhabits.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR068

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR068
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR068 genome assembly,

Gene Summary

Adenine Count

1206388 bp

Thymine Count

1215164 bp

Guanine Count

1626142 bp

Cytosine Count

1612800 bp

Genome Length

5660494 bp

Protein-coding Genes

5030 genes

Non-Coding Genes

338 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
multidrug transporter mdtdSAMEA3721100_00257Not AvailablePositive279414 - 28082950621.6
signal transduction histidine-protein kinase baesSAMEA3721100_00258Not AvailablePositive280826 - 28230454569.5
response regulator baerSAMEA3721100_00259Not AvailablePositive282301 - 28302327434.3
proteaseSAMEA3721100_00260Not AvailablePositive283342 - 28470351096.0
transcription regulatorSAMEA3721100_00261Not AvailablePositive284946 - 28584231929.6
2-deoxyglucose-6-phosphate hydrolase ynicSAMEA3721100_00262Not AvailableNegative286108 - 28677024060.8
ribitol/xylitol/arabitol transporterSAMEA3721100_00263Not AvailableNegative286819 - 28809646829.1
xylulose kinaseSAMEA3721100_00264Not AvailableNegative288167 - 28963052802.4
d-arabinitol dehydrogenaseSAMEA3721100_00265Not AvailableNegative289640 - 29100751014.7
putative sorc-family transcriptional regulatorSAMEA3721100_00266Not AvailablePositive291214 - 29215535020.0

Displaying genes 531 – 540 of 5368 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total